Solid tumours contain regions at very low oxygen concentrations (hypoxia), often
surrounding areas of necrosis. The cells in these hypoxic regions are resistant to both …

This review examines the vast catalytic and therapeutic potential offered by type I (ie oxygen-
insensitive) nitroreductase enzymes in partnership with nitroaromatic prodrugs, with …

In this study, the potential effects of bacteria on the efficacy of frequently used
chemotherapies was examined. Bacteria and cancer cell lines were examined in vitro and in …

In order to generate a zebrafish model of β cell regeneration, we have expressed an
Escherichia coli gene called nfsB in the β cells of embryonic zebrafish. This bacterial gene …

Anticancer prodrugs designed to target specifically tumor cells should increase therapeutic
effectiveness and decrease systemic side effects in the treatment of cancer. Over the last 20 …

Purpose: Hypoxia is a characteristic of solid tumors and a potentially important therapeutic
target. Here, we characterize the mechanism of action and preclinical antitumor activity of a …

Apoptosis is crucial for tissue homeostasis and organ development. In bone, apoptosis is
recognized to be a main fate of osteoblasts, yet the relevance of this process remains …

The principle of using suicide genes for gene directed enzyme prodrug therapy (GDEPT) of
cancer has gained increasing significance during the 20 years since its inception. The astute …

Chagas disease and African slee** sickness are trypanosomal infections that represent
important public health problems in Latin America and Africa, respectively. The restriction of …

Prodrugs are harmless until activated by a bacterial or viral gene product; they constitute the
basis of gene-delivered prodrug therapies called GDEPT, which can kill tumors without …