Defining postpartum uterine disease and the mechanisms of infection and immunity in the female reproductive tract in cattle

IM Sheldon, J Cronin, L Goetze, G Donofrio… - Biology of …, 2009 - academic.oup.com
Uterine microbial disease affects half of all dairy cattle after parturition, causing infertility by
disrupting uterine and ovarian function. Infection with Escherichia coli, Arcanobacterium …

The immunology of mammary gland of dairy ruminants between healthy and inflammatory conditions

M Ezzat Alnakip, M Quintela-Baluja… - Journal of veterinary …, 2014 - Wiley Online Library
The health of dairy animals, particularly the milk‐producing mammary glands, is essential to
the dairy industry because of the crucial hygienic and economic aspects of ensuring …

Mechanisms of infertility associated with clinical and subclinical endometritis in high producing dairy cattle

IM Sheldon, SB Price, J Cronin… - … in domestic animals, 2009 - Wiley Online Library
Contents Clinical and subclinical endometritis are common causes of infertility and
subfertility in high producing dairy cattle, delaying the onset of ovarian cyclic activity after …

Negative energy balance alters global gene expression and immune responses in the uterus of postpartum dairy cows

DC Wathes, Z Cheng, W Chowdhury… - Physiological …, 2009 - journals.physiology.org
Most dairy cows suffer uterine microbial contamination postpartum. Persistent endometritis
often develops, associated with reduced fertility. We used a model of differential feeding and …

Association between endometritis and endometrial cytokine expression in postpartum Holstein cows

KN Galvão, NR Santos, JS Galvão, RO Gilbert - Theriogenology, 2011 - Elsevier
The endometrium regulates the inflammatory response after infection by production and
release of cytokines and chemokines. The objective was to compare gene expression of …

Toll-like receptor and antimicrobial peptide expression in the bovine endometrium

D Davies, KG Meade, S Herath, PD Eckersall… - Reproductive Biology …, 2008 - Springer
Background The endometrium is commonly infected with bacteria leading to severe disease
of the uterus in cattle and humans. The endometrial epithelium is the first line of defence for …

Histopathological and molecular evaluation of Holstein-Friesian cows postpartum: toward an improved understanding of uterine innate immunity

A Chapwanya, KG Meade, ML Doherty, JJ Callanan… - Theriogenology, 2009 - Elsevier
Bovine uterine disease reduces milk yield, impairs fertility and has implications for animal
welfare. During involution, the uterus is usually exposed to multiple potential bacterial …

Bovine β-defensin gene family: opportunities to improve animal health?

KG Meade, P Cormican, F Narciandi… - Physiological …, 2014 - journals.physiology.org
Recent analysis of the bovine genome revealed an expanded suite of β-defensin genes that
encode what are referred to as antimicrobial or host defense peptides (HDPs). Whereas …

Broad-spectrum activity against bacterial mastitis pathogens and activation of mammary epithelial cells support a protective role of neutrophil cathelicidins in bovine …

L Tomasinsig, G De Conti, B Skerlavaj… - Infection and …, 2010 - journals.asm.org
Cathelicidins are peptide components of the innate immune system of mammals. Apart from
exerting a direct antibiotic activity, they can also trigger specific defense responses in the …

Time course of defense mechanisms in bovine endometrium in response to lipopolysaccharide

T Swangchan-Uthai, CRM Lavender… - Biology of …, 2012 - academic.oup.com
Endometritis caused by uterine infection after calving reduces fertility and causes major
economic losses to the dairy industry. This study investigated the time course of an …