MKK4 (mitogen-activated protein kinase kinase 4; also referred to as MEK4) is a dual-
specificity protein kinase that phosphorylates and regulates both JNK (c-Jun N-terminal …

The regenerative capabilities of the liver represent a paradigm for understanding tissue
repair in solid organs. Regeneration after partial hepatectomy in rodent models is well …

High-throughput nanomole-scale synthesis allows for late-stage functionalization (LSF) of
compounds in an efficient and economical manner. Here, we demonstrated that copper …

GZ17-6.02 is undergoing clinical evaluation in solid tumors and lymphoma. We defined the
biology of GZ17-6.02 in prostate cancer cells and determined whether it interacted with the …

A systematic strategy to develop dual-warhead inhibitors is introduced to circumvent the
limitations of conventional covalent inhibitors such as vulnerability to mutations of the …

Biomacromolecules, such as proteins, nucleic acids and polysaccharides, are widely
distributed in the human body, and some of them have been recognized as the targets of …

Radiotherapy is a common modality for cancer treatment. However, it is often associated
with normal tissue toxicity in 20–80% of the patients. Radioprotectors can improve the …

Growth, division, and development of healthy cells relies on efficient response to
environmental survival cues. The conserved mitogen-activated protein kinase (MAPK) family …

Cysteine-directed covalent ligands have emerged as a versatile category of chemical
probes and drugs that leverage thiol nucleophilicity to form permanent adducts with proteins …

The mitogen-activated protein kinase signaling cascade is conserved across eukaryotes,
where it plays a critical role in the regulation of activities including proliferation …