Listening to the data: computational approaches to addiction and learning
CS Wilkinson, MÁ Luján, C Hales… - Journal of …, 2023 - Soc Neuroscience
Computational approaches hold great promise for identifying novel treatment targets and
creating translational therapeutics for substance use disorders. From circuitries underlying …
creating translational therapeutics for substance use disorders. From circuitries underlying …
Ten points to improve reproducibility and translation of animal research
R Spanagel - Frontiers in behavioral neuroscience, 2022 - frontiersin.org
Findings from animal experiments are often difficult to transfer to humans. In this perspective
article I discuss two questions. First, why are the results of animal experiments often so …
article I discuss two questions. First, why are the results of animal experiments often so …
Distinct behavioral profiles and neuronal correlates of heroin vulnerability versus resiliency in a multi-symptomatic model of heroin use disorder in rats
BN Kuhn, N Cannella, AD Crow… - American Journal of …, 2025 - psychiatryonline.org
Objective: The behavioral and diagnostic heterogeneity within the opioid use disorder
(OUD) diagnosis is not readily captured in current animal models, limiting the translational …
(OUD) diagnosis is not readily captured in current animal models, limiting the translational …
Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in the rat
N Cannella, S Tambalo, V Lunerti, G Scuppa… - Brain, Behavior, and …, 2024 - Elsevier
In opioid use disorder (OUD) patients, a decrease in brain grey matter volume (GMV) has
been reported. It is unclear whether this is the consequence of prolonged exposure to …
been reported. It is unclear whether this is the consequence of prolonged exposure to …
A multi-symptomatic model of heroin use disorder in rats reveals distinct behavioral profiles and neuronal correlates of heroin vulnerability versus resiliency
BN Kuhn, N Cannella, AD Crow, V Lunerti, A Gupta… - BioRxiv, 2024 - biorxiv.org
Objective The behavioral and diagnostic heterogeneity within human opioid use disorder
(OUD) diagnosis is not readily captured in current animal models, limiting translational …
(OUD) diagnosis is not readily captured in current animal models, limiting translational …
Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats
The increased prevalence of opioid use disorder (OUD) makes it imperative to disentangle
the biological mechanisms contributing to individual differences in OUD vulnerability. OUD …
the biological mechanisms contributing to individual differences in OUD vulnerability. OUD …
Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats
The increased prevalence of opioid use disorder (OUD) makes it imperative to disentangle
the biological mechanisms contributing to individual differences in OUD vulnerability. OUD …
the biological mechanisms contributing to individual differences in OUD vulnerability. OUD …