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The PI3K pathway in human disease
Phosphoinositide 3-kinase (PI3K) activity is stimulated by diverse oncogenes and growth
factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K …
factor receptors, and elevated PI3K signaling is considered a hallmark of cancer. Many PI3K …
Tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple
organ systems and is caused by loss-of-function mutations in one of two genes: TSC1 or …
organ systems and is caused by loss-of-function mutations in one of two genes: TSC1 or …
[HTML][HTML] Tuberous sclerosis complex diagnostic criteria update: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference
H Northrup, DA Krueger, S Roberds, K Smith… - Pediatric …, 2013 - Elsevier
Background Tuberous sclerosis complex is highly variable in clinical presentation and
findings. Disease manifestations continue to develop over the lifetime of an affected …
findings. Disease manifestations continue to develop over the lifetime of an affected …
Neurological and neuropsychiatric aspects of tuberous sclerosis complex
Tuberous sclerosis (also known as tuberous sclerosis complex [TSC]) is a multisystem
genetic disorder that affects almost every organ in the body. Mutations in the TSC1 or TSC2 …
genetic disorder that affects almost every organ in the body. Mutations in the TSC1 or TSC2 …
Sex and gender differences in lung disease
P Silveyra, N Fuentes, DE Rodriguez Bauza - Lung Inflammation in Health …, 2021 - Springer
Sex differences in the anatomy and physiology of the respiratory system have been widely
reported. These intrinsic sex differences have also been shown to modulate the …
reported. These intrinsic sex differences have also been shown to modulate the …
Official American Thoracic Society/Japanese Respiratory Society clinical practice guidelines: lymphangioleiomyomatosis diagnosis and management
Background: Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that primarily
affects women. The purpose of these guidelines is to provide recommendations for the …
affects women. The purpose of these guidelines is to provide recommendations for the …
Perfect match: mTOR inhibitors and tuberous sclerosis complex
C Luo, WR Ye, W Shi, P Yin, C Chen, YB He… - Orphanet journal of rare …, 2022 - Springer
Tuberous sclerosis complex (TSC) is an autosomal dominant syndrome that presents with
diverse and complex clinical features and involves multiple human systems. TSC-related …
diverse and complex clinical features and involves multiple human systems. TSC-related …
Pneumothorax: classification and etiology
NC Huan, C Sidhu, R Thomas - Clinics in Chest Medicine, 2021 - chestmed.theclinics.com
Pneumothorax is a common clinical problem worldwide. 1 Pneumothorax is defined as
presence of air in the pleural cavity. It can develop secondary to diverse etiologies including …
presence of air in the pleural cavity. It can develop secondary to diverse etiologies including …
Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells
Understanding the aging process and ways to manipulate it is of major importance for
biology and medicine. Among the many aging theories advanced over the years, the …
biology and medicine. Among the many aging theories advanced over the years, the …
Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment
Abstract mTORC1 is hyperactive in multiple cancer types,. Here, we performed integrative
analysis of single cell transcriptomic profiling, paired T cell receptor (TCR) sequencing, and …
analysis of single cell transcriptomic profiling, paired T cell receptor (TCR) sequencing, and …