The discovery of natural RNA enzymes (ribozymes) prompted the pursuit of artificial DNA
enzymes (deoxyribozymes) by in vitro selection methods. A key motivation is the conceptual …

In cells, DNA typically consists of two antiparallel strands arranged in a double-helical
structure, which is central to its fundamental role in storing and transmitting genetic …

One of the chemist's key motivations is to explore the forefront of catalysis. In this Account,
we describe our laboratory's efforts at one such forefront: the use of DNA as a catalyst …

Deoxyribozymes, DNA enzymes or simply DNAzymes are single-stranded oligo-
deoxyribonucleotide molecules that, like proteins and ribozymes, possess the ability to …

Single-nucleotide polymorphisms, either inherited or due to spontaneous DNA damage, are
associated with numerous diseases. Develo** tools for site-specific nucleotide …

This study focuses on the development of DNA catalysts (deoxyribozymes) that modify side
chains of peptide substrates, with the long-term goal of achieving DNA-catalyzed covalent …

Background: Although catalytic RNA enzymes (CRzs) are naturally occurring in many
organisms, their DNA counterparts (CDzs) were developed by in vitro selection/evolution …

I-R3 DNAzyme is a small, highly active catalytic DNA for DNA hydrolysis. In here, we
designed two cis-structure DNAzymes (I-R3N and I-R3S) based on the different locates of …

The focus of this work was the development and application of highly efficient RNA catalysts
for the site-specific modification of RNA with special focus on methylation. In the course of …

2023-05-26 Assigned to THE BOARD OF TRUSTEES OF THE LELAND STANFORD
JUNIOR UNIVERSITY reassignment THE BOARD OF TRUSTEES OF THE LELAND …