General anaesthesia is usually considered to safely induce a reversible brain state allowing
the performance of surgery under optimal conditions. An increasing number of clinical and …

A large number of studies during the past two decades have demonstrated the efficacy and
safety of sevoflurane across patient populations. Clinical researchers have also investigated …

Background Few studies of how exposure of children to anesthesia may affect
neurodevelopment employ comprehensive neuropsychological assessments. This study …

Background In laboratory animals, exposure to most general anaesthetics leads to
neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition …

Importance Exposure of young animals to commonly used anesthetics causes neurotoxicity
including impaired neurocognitive function and abnormal behavior. The potential …

Background Preclinical data suggest that general anaesthetics affect brain development.
There is mixed evidence from cohort studies that young children exposed to anaesthesia …

BACKGROUND: Annually, millions of children are exposed to anesthetic agents that cause
apoptotic neurodegeneration in immature animals. To explore the possible significance of …

BACKGROUND: Over the past decade, the safety of anesthetic agents in children has been
questioned after the discovery that immature animals exposed to anesthesia display …

Background Exposure of young animals to general anesthesia (GA) causes
neurodegeneration and lasting behavioral abnormalities; whether these findings translate to …

Importance The results of preclinical studies suggest that anesthetic drugs administered to
neonatal animals cause widespread neuronal apoptosis and later neurocognitive …