The use of metabolomics to dissect plant responses to abiotic stresses

T Obata, AR Fernie - Cellular and Molecular Life Sciences, 2012 - Springer
Plant metabolism is perturbed by various abiotic stresses. As such the metabolic network of
plants must be reconfigured under stress conditions in order to allow both the maintenance …

Metabolic phenoty** in clinical and surgical environments

JK Nicholson, E Holmes, JM Kinross, AW Darzi… - Nature, 2012 - nature.com
Metabolic phenoty** involves the comprehensive analysis of biological fluids or tissue
samples. This analysis allows biochemical classification of a person's physiological or …

Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner

R Shiratori, K Furuichi, M Yamaguchi, N Miyazaki… - Scientific reports, 2019 - nature.com
Most cancer cells rely on glycolysis to generate ATP, even when oxygen is available.
However, merely inhibiting the glycolysis is insufficient for the eradication of cancer cells …

Mass spectrometric based approaches in urine metabolomics and biomarker discovery

MM Khamis, DJ Adamko… - Mass spectrometry …, 2017 - Wiley Online Library
Urine metabolomics has recently emerged as a prominent field for the discovery of non‐
invasive biomarkers that can detect subtle metabolic discrepancies in response to a specific …

New advances in separation science for metabolomics: resolving chemical diversity in a post-genomic era

NL Kuehnbaum, P Britz-McKibbin - Chemical reviews, 2013 - ACS Publications
Metabolomics offers a revolutionary framework for phenoty** individuals at a molecular
level that is needed for new breakthroughs in cell biology and personalized medicine. 1− 3 …

Untargeted LC/MS-based metabolic phenoty** (metabonomics/metabolomics): The state of the art

H Gika, C Virgiliou, G Theodoridis, RS Plumb… - … of Chromatography B, 2019 - Elsevier
Liquid chromatography (LC) hyphenated to mass spectrometry is currently the most widely
used means of determining metabolic phenotypes via both untargeted and targeted …

CE‐MS for metabolomics: Developments and applications in the period 2018–2020

W Zhang, R Ramautar - Electrophoresis, 2021 - Wiley Online Library
Capillary electrophoresis‐mass spectrometry (CE‐MS) is now a mature analytical technique
in metabolomics, notably for the efficient profiling of polar and charged metabolites. Over the …

Bioinformatics tools for mass spectroscopy-based metabolomic data processing and analysis

M Sugimoto, M Kawakami, M Robert… - Current …, 2012 - ingentaconnect.com
Biological systems are increasingly being studied in a holistic manner, using omics
approaches, to provide quantitative and qualitative descriptions of the diverse collection of …

Advances in metabolite identification

DS Wishart - Bioanalysis, 2011 - Taylor & Francis
One of the central challenges to metabolomics is metabolite identification. Regardless of
whether one uses so-called 'targeted'or 'untargeted'metabolomics, eventually all paths lead …

Metabolomics in plant stress physiology

A Ghatak, P Chaturvedi, W Weckwerth - Plant genetics and molecular …, 2018 - Springer
Metabolomics is an essential technology for functional genomics and systems biology. It
plays a key role in functional annotation of genes and understanding towards cellular and …