Cellular and molecular mechanisms underlying prostate cancer development: therapeutic implications
Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
Therapy considerations in neuroendocrine prostate cancer: what next?
Lineage plasticity and histologic transformation to small cell neuroendocrine prostate cancer
(NEPC) is an increasingly recognized mechanism of treatment resistance in advanced …
(NEPC) is an increasingly recognized mechanism of treatment resistance in advanced …
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR)
dependence leads to clinically aggressive tumors with few therapeutic options. We used …
dependence leads to clinically aggressive tumors with few therapeutic options. We used …
The role of lineage plasticity in prostate cancer therapy resistance
H Beltran, A Hruszkewycz, HI Scher, J Hildesheim… - Clinical cancer …, 2019 - AACR
Lineage plasticity has emerged as an important mechanism of treatment resistance in
prostate cancer. Treatment-refractory prostate cancers are increasingly associated with loss …
prostate cancer. Treatment-refractory prostate cancers are increasingly associated with loss …
ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis
Abstract Treatment of prostate cancer (PC) by androgen suppression promotes the
emergence of aggressive variants that are androgen receptor (AR) independent. Here we …
emergence of aggressive variants that are androgen receptor (AR) independent. Here we …
The 5-hydroxymethylcytosine landscape of prostate cancer
M Sjöström, SG Zhao, S Levy, M Zhang, Y Ning… - Cancer research, 2022 - AACR
Abstract Analysis of DNA methylation is a valuable tool to understand disease progression
and is increasingly being used to create diagnostic and prognostic clinical biomarkers …
and is increasingly being used to create diagnostic and prognostic clinical biomarkers …
Integrative multi‐omics analysis of intestinal organoid differentiation
Intestinal organoids accurately recapitulate epithelial homeostasis in vivo, thereby
representing a powerful in vitro system to investigate lineage specification and cellular …
representing a powerful in vitro system to investigate lineage specification and cellular …
Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
F Chen, Q Long, D Fu, D Zhu, Y Ji, L Han… - Nature …, 2018 - nature.com
Chemotherapy and radiation not only trigger cancer cell apoptosis but also damage stromal
cells in the tumour microenvironment (TME), inducing a senescence-associated secretory …
cells in the tumour microenvironment (TME), inducing a senescence-associated secretory …
Control of cell identity by the nuclear receptor HNF4 in organ pathophysiology
Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear
receptor family whose expression and activities are restricted to a limited number of organs …
receptor family whose expression and activities are restricted to a limited number of organs …
Nucleosome patterns in circulating tumor DNA reveal transcriptional regulation of advanced prostate cancer phenotypes
Advanced prostate cancers comprise distinct phenotypes, but tumor classification remains
clinically challenging. Here, we harnessed circulating tumor DNA (ctDNA) to study tumor …
clinically challenging. Here, we harnessed circulating tumor DNA (ctDNA) to study tumor …