The cytoprotective keratins (K) compose the intermediate filaments of epithelial cells and
their inherited and spontaneous mutations give rise to keratinopathies. For example …

Keratins are essential elements of the cytoskeleton of normal and malignant epithelial cells.
Because carcinomas commonly maintain their specific keratin expression pattern during …

The mammalian epidermis is a stratified epithelium that protects the body against
mechanical force, dehydration, and infections. These functions rely on a series of …

Abstract Keratin 8 (K8) is the main intestinal epithelial intermediate filament protein with
proposed roles for colonic epithelial cell integrity. Here, we used mice lacking K8 in …

Keratins (K) are intermediate filament proteins important in stress protection and mechanical
support of epithelial tissues. K8, K18 and K19 are the main colonic keratins, and K8 …

Simple-type epithelial keratins are intermediate filament proteins important for mechanical
stability and stress protection. Keratin mutations predispose to human liver disorders …

Aim Abnormally activated vascular smooth muscle cells are key factors in pulmonary artery
remodelling (PAR) and pulmonary artery hypertension (PAH). Keratin 1 is involved in …

Pollution of the environment represents one of less explored potential reasons for the
worldwide epidemic of type 2 diabetes. One of the most prevalent organochlorine pollutants …

The piwi-like 2 (piwil2) gene is widely expressed in tumors and protects cells from apoptosis
induced by a variety of stress stimuli. However, the role of Piwil2 in Fas-mediated apoptosis …

Keratin (K) 7 is an intermediate filament protein expressed in ducts and glands of simple
epithelial organs and in urothelial tissues. In the pancreas, K7 is expressed in exocrine …