The melanocortin 1 receptor (MC1R) is a melanocytic Gs protein coupled receptor that
regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic …

Epidermal melanocytes are particularly vulnerable to oxidative stress owing to the pro-
oxidant state generated during melanin synthesis, and to the intrinsic antioxidant defenses …

In this present study, a newly isolated strain, Streptomyces sp. NEAE-H, capable of
producing high amount of black extracellular melanin pigment on peptone-yeast extract iron …

Everyone knows and seems to agree that melanocytes are there to generate melanin–an
intriguing, but underestimated multipurpose molecule that is capable of doing far more than …

Despite many efforts, regulation of skin and hair pigmentation is still not fully understood.
This article focuses mainly on controversial aspects in pigment cell biology which have …

The biological pigment melanin is present in most of the biological systems. It manifests a
host of biological and pharmacological properties. Its role as a molecule with special …

Terrestrial solar ultraviolet radiation (UVR) exerts both beneficial and adverse effects on
human skin. Epidemiological studies show a lower incidence of skin cancer in people with …

Skin cancer incidence is dramatically increasing worldwide, with exposure to ultraviolet
radiation (UVR) a predominant factor. The UVA component initiates oxidative stress in …

High mortality rate for metastatic melanoma is related to its resistant to the current methods
of therapy. Melanogenesis is a metabolic pathway characteristic for normal and malignant …

It is widely accepted that antioxidants, either endogenous or from the diet, play a key role in
preserving health. They are able to quench radical species generated in situations of …