The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Rationale: MicroRNA (miR)-133a regulates cardiac and skeletal muscle differentiation and
plays an important role in cardiac development. Because miR-133a levels decrease during …

The intrinsic electrical properties of neurons are shaped in large part by the action of voltage-
gated ion channels. Molecular cloning studies have revealed a large family of ion channel …

In the mammalian heart, Ca2+‐independent, depolarization‐activated potassium (K+)
currents contribute importantly to sha** the waveforms of action potentials, and several …

We have developed a mathematical model of the mouse ventricular myocyte action potential
(AP) from voltage-clamp data of the underlying currents and Ca2+ transients. Wherever …

Shal-type (Kv4. x) K+ channels are expressed in a variety of tissue, with particularly high
levels in the brain and heart. These channels are the primary subunits that contribute to …

KChIP2, a gene encoding three auxiliary subunits of Kv4. 2 and Kv4. 3, is preferentially
expressed in the adult heart, and its expression is downregulated in cardiac hypertrophy …

The inwardly rectifying K+ channel Kir6. 1 forms K+ channels by coupling with a sulfonylurea
receptor in reconstituted systems, but the physiological roles of Kir6. 1-containing K+ …