Adropin's role in energy homeostasis and metabolic disorders

II Ali, C D'Souza, J Singh, E Adeghate - International journal of molecular …, 2022 - mdpi.com
Adropin is a novel 76-amino acid-peptide that is expressed in different tissues and cells
including the liver, pancreas, heart and vascular tissues, kidney, milk, serum, plasma and …

Adipose tissue secretion pattern influences β-cell wellness in the transition from obesity to type 2 diabetes

G Biondi, N Marrano, A Borrelli, M Rella… - International Journal of …, 2022 - mdpi.com
The dysregulation of the β-cell functional mass, which is a reduction in the number of β-cells
and their ability to secure adequate insulin secretion, represents a key mechanistic factor …

Irisin alleviates FFA induced β-cell insulin resistance and inflammatory response through activating PI3K/AKT/FOXO1 signaling pathway

S Zheng, N Chen, X Kang, Y Hu, S Shi - Endocrine, 2022 - Springer
Purpose Type 2 diabetes mellitus is characterized by insulin resistance and β-cell
dysfunction. Elevated free fatty acids-induced lipotoxicity may play a vital role in the …

Type 2 diabetes and Alzheimer's disease: the emerging role of cellular lipotoxicity

N Marrano, G Biondi, A Borrelli, M Rella, T Zambetta… - Biomolecules, 2023 - mdpi.com
Type 2 diabetes (T2D) and Alzheimer's diseases (AD) represent major health issues that
have reached alarming levels in the last decades. Although growing evidence demonstrates …

Irisin/PGC-1α/FNDC5 pathway in Parkinson's disease: truth under the throes

NH Ali, NA Alhamdan, HM Al-Kuraishy… - Naunyn-Schmiedeberg's …, 2024 - Springer
Parkinson's disease (PD) is considered one of the most common neurodegenerative brain
diseases which involves the deposition of α-synuclein. Irisin hormone, a newly discovered …

Irisin: an anti-inflammatory exerkine in aging and redox-mediated comorbidities

CS Trettel, BRA Pelozin, MP Barros… - Frontiers in …, 2023 - frontiersin.org
Human beings lead largely sedentary lives. From an evolutionary perspective, such lifestyle
is not beneficial to health. Exercise can promote many enabling pathways, particularly …

Role of Irisin in Endocrine and Metabolic Disorders—Possible New Therapeutic Agent?

L Leustean, C Preda, L Teodoriu, L Mihalache… - Applied Sciences, 2021 - mdpi.com
Irisin is a novel hormone that provides a possible solution for the treatment of metabolic
disorders. Discovered in 2012 by Boström et al., irisin very quickly became an interesting …

[HTML][HTML] Prevention of Alzheimer's disease through diet: an exploratory review

NZ Bhuiyan, MK Hasan, Z Mahmud, MS Hossain… - Metabolism Open, 2023 - Elsevier
Introduction This exploratory review article describes about the genetic factors behind
Alzheimer's disease (AD), their association with foods, and their relationships with cognitive …

Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators

МB Chernysheva, ЕS Ruchko, МV Karimova… - Frontiers in Cell and …, 2024 - frontiersin.org
Pancreatic regeneration is a complex process observed in both normal and pathological
conditions. The aim of this review is to provide a comprehensive understanding of the …

Exploring the potential roles of apelin, visfatin, and irisin in energy regulation in farm animals: an overview

B Shokrollahi, SS Jang, HJ Lee, HI Ahmad… - Frontiers in Veterinary …, 2024 - frontiersin.org
Adipose tissue, both intricate and fundamental to physiological functions, comprises cell
types, including adipocytes, pivotal in secreting bioactive peptides known as …