With the increasing life expectancy in developed countries, the incidence of Alzheimer's
disease (AD) and thus its socioeconomic impact are growing. Increasing knowledge over …

The brain is unique among organs in many respects, including its mechanisms of lipid
synthesis and energy production. The nervous system-specific metabolite N-acetylaspartate …

Amyloid-β (Aβ) deposits have been identified as key players in the progression of
Alzheimer's disease (AD). Recent evidence indicates that the deposits probably precede …

In this article, we first designed and synthesized curcumin-based near-infrared (NIR)
fluorescence imaging probes for detecting both soluble and insoluble amyloid beta (Aβ) …

Beta amyloid is a protein fragment snipped from the amyloid precursor protein (APP).
Aggregation of these peptides into amyloid plaques is one of the hallmarks of Alzheimer's …

Near-infrared fluorescence (NIRF) molecular imaging has been widely applied to monitoring
therapy of cancer and other diseases in preclinical studies; however, this technology has not …

Altered iron metabolism has been hypothesized to be associated with Alzheimer's disease
pathology, and prior work has shown associations between iron load and beta amyloid …

Obtaining a histological fingerprint from the in-vivo brain has been a long-standing target of
magnetic resonance imaging (MRI). In particular, non-invasive imaging of iron and myelin …

Quantitative susceptibility map** (QSM) has been used to study susceptibility changes
that may occur based on tissue composition and mineral deposition. Iron is a primary …

Abnormal iron distribution in the isocortex is increasingly recognized as an in vivo marker for
Alzheimer's disease (AD). However, the contribution of iron accumulation to the AD …