Targeting secondary injury in intracerebral haemorrhage—perihaematomal oedema

S Urday, WT Kimberly, LA Beslow… - Nature Reviews …, 2015 - nature.com
Perihaematomal oedema (PHO) is an important pathophysiological marker of secondary
injury in intracerebral haemorrhage (ICH). In this Review, we describe a novel method to …

Perihematomal edema after spontaneous intracerebral hemorrhage

N Ironside, CJ Chen, D Ding, SA Mayer, ES Connolly Jr - Stroke, 2019 - Am Heart Assoc
Ironside et al Perihematomal Edema and ICH 1627 common pathway of the coagulation
cascade. 39 Thrombin can also induce PHE formation independent of fibrinogen, which …

Intensive blood-pressure lowering in patients with acute cerebral hemorrhage

AI Qureshi, YY Palesch, WG Barsan… - … England Journal of …, 2016 - Mass Medical Soc
Background Limited data are available to guide the choice of a target for the systolic blood-
pressure level when treating acute hypertensive response in patients with intracerebral …

Blood pressure variability predicts poor in-hospital outcome in spontaneous intracerebral hemorrhage

AA Divani, XI Liu, M Di Napoli, S Lattanzi, W Ziai… - Stroke, 2019 - Am Heart Assoc
Background and Purpose—There is increasing evidence that higher systolic blood pressure
variability (SBPV) may be associated with poor outcome in patients with intracerebral …

[PDF][PDF] Effects of stroke on the autonomic nervous system

AM Dorrance, G Fink - Compr Physiol, 2015 - academia.edu
Stroke is the fourth leading cause of death in the United States and the second most
common cause of death worldwide; stroke is also the leading cause of long-term disability …

Association between hyperacute stage blood pressure variability and outcome in patients with spontaneous intracerebral hemorrhage

PW Chung, JT Kim, N Sanossian, S Starkmann… - Stroke, 2018 - Am Heart Assoc
Background and Purpose—Increased blood pressure (BP) variability, in addition to high BP,
may contribute to adverse outcome in intracerebral hemorrhage. However, degree and …

Molecular, pathological, clinical, and therapeutic aspects of perihematomal edema in different stages of intracerebral hemorrhage

C Jiang, H Guo, Z Zhang, Y Wang, S Liu… - Oxidative Medicine …, 2022 - Wiley Online Library
Acute intracerebral hemorrhage (ICH) is a devastating type of stroke worldwide. Neuronal
destruction involved in the brain damage process caused by ICH includes a primary injury …

From hypertension to stroke: mechanisms and potential prevention strategies

JG Yu, RR Zhou, GJ Cai - CNS neuroscience & therapeutics, 2011 - Wiley Online Library
Stroke is a major cause of disability and death worldwide. Prevention aimed at risk factors of
stroke is the most effective strategy to curb the stroke pandemic. Hypertension is one of the …

Factors associated with early deterioration after spontaneous intracerebral hemorrhage: a systematic review and meta-analysis

AV Specogna, TC Turin, SB Patten, MD Hill - PloS one, 2014 - journals.plos.org
Background and Purpose Spontaneous intracerebral hemorrhage (ICH) is a devastating
form of stroke with a poor prognosis overall. We conducted a systematic review and meta …

Baroreflex: a new therapeutic target in human stroke?

M Sykora, J Diedler, P Turcani, W Hacke, T Steiner - Stroke, 2009 - Am Heart Assoc
Background and Purpose—Autonomic dysfunction, including increased sympathetic drive
and blunted baroreflex, has repeatedly been observed in acute stroke. Of clinical importance …