[HTML][HTML] A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics

RNL Lamptey, B Chaulagain, R Trivedi… - International journal of …, 2022 - mdpi.com
Neurodegenerative disorders are primarily characterized by neuron loss. The most common
neurodegenerative disorders include Alzheimer's and Parkinson's disease. Although there …

Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

K Mitusova, OO Peltek, TE Karpov… - Journal of …, 2022 - Springer
Besides the broad development of nanotechnological approaches for cancer diagnosis and
therapy, currently, there is no significant progress in the treatment of different types of brain …

Nanomaterial based drug delivery systems for the treatment of neurodegenerative diseases

SM Asil, J Ahlawat, GG Barroso, M Narayan - Biomaterials science, 2020 - pubs.rsc.org
With an aging population that has been increasing in recent years, the need for the
development of therapeutic approaches for treatment of neurodegenerative disorders (ND) …

Antioxidants and nanotechnology: promises and limits of potentially disruptive approaches in the treatment of central nervous system diseases

C Martinelli, C Pucci, M Battaglini… - Advanced …, 2020 - Wiley Online Library
Many central nervous system (CNS) diseases are still incurable and only symptomatic
treatments are available. Oxidative stress is suggested to be a common hallmark, being able …

Brain injury-induced dysfunction of the blood brain barrier as a risk for dementia

EE Abrahamson, MD Ikonomovic - Experimental neurology, 2020 - Elsevier
The blood-brain barrier (BBB) is a complex and dynamic physiological interface between
brain parenchyma and cerebral vasculature. It is composed of closely interacting cells and …

Astrocyte-targeted siRNA delivery by adenosine-functionalized LNP in mouse TBI model

H **ao, O Amarsaikhan, Y Zhao, X Yu, X Hu… - … Therapy Nucleic Acids, 2023 - cell.com
Traumatic brain injury (TBI) induces pro-inflammatory polarization of astrocytes and causes
secondary disruption of the blood-brain barrier (BBB) and brain damage. Herein, we report a …

Exploring the potential of nanotechnology in pediatric healthcare: advances, challenges, and future directions

H Omidian, K Mfoafo - Pharmaceutics, 2023 - mdpi.com
The utilization of nanotechnology has brought about notable advancements in the field of
pediatric medicine, providing novel approaches for drug delivery, disease diagnosis, and …

[HTML][HTML] Nanoparticle-based technology approaches to the management of neurological disorders

TM Sim, D Tarini, ST Dheen, BH Bay… - International Journal of …, 2020 - mdpi.com
Neurological disorders are the most devastating and challenging diseases associated with
the central nervous system (CNS). The blood-brain barrier (BBB) maintains homeostasis of …

[HTML][HTML] Microfluidic development of brain-derived neurotrophic factor loaded solid lipid nanoparticles: an in vitro evaluation in the post-traumatic brain injury …

F Sommonte, I Arduino, RM Iacobazzi, L Laera… - Journal of Drug Delivery …, 2024 - Elsevier
Microfluidic-based nanoscale drug delivery systems have risen to prominence in the field of
precision nanomedicine in recent years. This intriguing innovation could provide unique …

Tailored reconstituted lipoprotein for site-specific and mitochondria-targeted cyclosporine a delivery to treat traumatic brain injury

L Chen, Q Song, Y Chen, S Meng, M Zheng, J Huang… - ACS …, 2020 - ACS Publications
The secondary damage in traumatic brain injury (TBI) can lead to lifelong disabilities,
bringing enormous economic and psychological burden to patients and their families …