Overview and considerations in bottom-up proteomics

RM Miller, LM Smith - Analyst, 2023 - pubs.rsc.org
Proteins are the key biological actors within cells, driving many biological processes integral
to both healthy and diseased states. Understanding the depth of complexity represented …

Computational methods for understanding mass spectrometry–based shotgun proteomics data

P Sinitcyn, JD Rudolph, J Cox - Annual Review of Biomedical …, 2018 - annualreviews.org
Computational proteomics is the data science concerned with the identification and
quantification of proteins from high-throughput data and the biological interpretation of their …

Enhanced protein isoform characterization through long-read proteogenomics

RM Miller, BT Jordan, MM Mehlferber, ED Jeffery… - Genome biology, 2022 - Springer
Background The detection of physiologically relevant protein isoforms encoded by the
human genome is critical to biomedicine. Mass spectrometry (MS)-based proteomics is the …

X! TandemPipeline: a tool to manage sequence redundancy for protein inference and phosphosite identification

O Langella, B Valot, T Balliau… - Journal of proteome …, 2017 - ACS Publications
X! TandemPipeline is a software designed to perform protein inference and to manage
redundancy in the results of phosphosite identification by database search. It provides the …

Critical Assessment of MetaProteome Investigation (CAMPI): a multi-laboratory comparison of established workflows

T Van Den Bossche, BJ Kunath, K Schallert… - Nature …, 2021 - nature.com
Metaproteomics has matured into a powerful tool to assess functional interactions in
microbial communities. While many metaproteomic workflows are available, the impact of …

Mass spectrometry–based protein identification in proteomics—a review

Z Noor, SB Ahn, MS Baker… - Briefings in …, 2021 - academic.oup.com
Statistically, accurate protein identification is a fundamental cornerstone of proteomics and
underpins the understanding and application of this technology across all elements of …

A critical analysis of research methods and experimental models to study the root canal microbiome

JF Siqueira Jr, IN Rôças - International Endodontic Journal, 2022 - Wiley Online Library
Endodontic microbiology deals with the study of the microbial aetiology and pathogenesis of
pulpal and periradicular inflammatory diseases. Research in endodontic microbiology …

Challenges and promise at the interface of metaproteomics and genomics: an overview of recent progress in metaproteogenomic data analysis

H Schiebenhoefer, T Van Den Bossche… - Expert Review of …, 2019 - Taylor & Francis
Introduction: The study of microbial communities based on the combined analysis of
genomic and proteomic data–called metaproteogenomics–has gained increased research …

Quantification of snake venom proteomes by mass spectrometry‐considerations and perspectives

JJ Calvete, B Lomonte, AJ Saviola… - Mass Spectrometry …, 2024 - Wiley Online Library
The advent of soft ionization mass spectrometry‐based proteomics in the 1990s led to the
development of a new dimension in biology that conceptually allows for the integral analysis …

gpGrouper: a peptide grou** algorithm for gene-centric inference and quantitation of bottom-up proteomics data

AB Saltzman, M Leng, B Bhatt, P Singh… - Molecular & Cellular …, 2018 - ASBMB
In quantitative mass spectrometry, the method by which peptides are grouped into proteins
can have dramatic effects on downstream analyses. Here we describe gpGrouper, an …