Neuronal circuits in the brain are shaped by experience during'critical periods' in early
postnatal life. In the primary visual cortex, this activity-dependent development is triggered …

▪ Abstract Neuronal circuits are shaped by experience during critical periods of early
postnatal life. The ability to control the timing, duration, and closure of these heightened …

Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

In the mature brain, GABA (γ-aminobutyric acid) functions primarily as an inhibitory
neurotransmitter. But it can also act as a trophic factor during nervous system development …

The potency of the environment to shape brain function changes dramatically across the
lifespan. Neural circuits exhibit profound plasticity during early life and are later stabilized. A …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

The authors review the available literature on the preclinical and clinical studies involving
GABAergic neurotransmission in mood disorders. γ-Aminobutyric acid (GABA) is an …

Cerebral cortical functions are conducted by two general classes of neurons: glutamatergic
projection neurons and GABAergic interneurons. Distinct interneuron subtypes serve distinct …

The role of γ-aminobutyric acid (GABA) as a signal in animals has been documented for
over 60 years. In contrast, evidence that GABA is a signal in plants has only emerged in the …

Here we describe mechanisms regulating area patterning of develo** mammalian
neocortex, referred to as arealization. Current findings indicate an interplay between intrinsic …