Genomic technologies have led to massive gains in our understanding of human gene
function and disease relevance. Chemical biologists are a primary beneficiary of this …

Molecules that are able to induce proximity between two proteins are finding ever increasing
applications in chemical biology and drug discovery. The ability to introduce an electrophile …

β-catenin (CTNNB1) is an oncogenic transcription factor that is important in cell–cell
adhesion and transcription of cell proliferation and survival genes that drive the …

Cysteine chemoproteomic screening platforms are widely utilized for chemical probe and
drug discovery campaigns. Chemoproteomic compound screens, which use a mass …

Pioneer transcription factors (TFs) bind to and open closed chromatin, facilitating
engagement by other regulatory factors involved in gene activation or repression. Chemical …

Adenanthin is a structurally unique ent-kaurane diterpenoid isolated from Rabdosia
adenantha, a traditional Chinese medicinal plant with potent anti-cancer and anti …

A simple, modular, programmable approach to access complex stereopure azetidines
through strain-release functionalization is disclosed. The synthetic methods developed …

The chromosomal theory of inheritance dictates that genes on the same chromosome
segregate together while genes on different chromosomes assort independently …

Many chemotherapeutics target metabolic processes associated with DNA replication and
transcription to induce cell death. While traditional chemotherapeutics that inhibit DNA …

Cellular activities are predominantly carried out by proteins that can dynamically adopt
different structural conformations and differentially interact with other biomolecules …