Programmed cell death protein 1 (PD-1) blockade targeting the PD-1 immune checkpoint
has demonstrated unprecedented clinical efficacy in the treatment of advanced cancers …

The PD-1 pathway is a cornerstone in immune regulation. While the PD-1 pathway has
received considerable attention for its role in contributing to the maintenance of T cell …

Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the
tumor microenvironment, favoring immunosuppression and tumor growth. We discovered …

Background Programmed death 1 (PD-1) is an immunologic checkpoint that limits immune
responses by delivering potent inhibitory signals to T cells on interaction with specific …

Mesenchymal stromal cells (MSCs) exert broad immunosuppressive potential, modulating
the activity of cells of innate and adaptive immune systems. As MSCs become accepted as a …

Current cancer immunotherapies target immune checkpoint molecules such as the inhibitory
receptor programmed cell death-1 (PD-1), one of its ligands, programmed cell death ligand …

RCC is considered an immunogenic tumor with a prominent dysfunctional immune cell
infiltrate, unable to control tumor growth. Evasion of immune surveillance, a process defined …

The identification of inhibitory NK cell receptors specific for HLA-I molecules (KIRs and
NKG2A) provided the molecular basis for clarifying the mechanism by which NK cells kill …

Interactions between different cell types are essential for multiple biological processes,
including immunity, embryonic development and neuronal signalling. Although the …

Abstract The programmed death (PD)-1/PD-1 ligands (PD-Ls) pathway, is a new member of
the B7/CD28 family, and consists of the PD-1 receptor and its ligands PD-L1 (B7-H1 …