Gene drives gaining speed
E Bier - Nature Reviews Genetics, 2022 - nature.com
Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …
Combating mosquito-borne diseases using genetic control technologies
Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …
burdens. Unfortunately, current control methods based on insecticides and environmental …
Antimalarial drug discovery: Progress and approaches
Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …
overcome emerging drug resistance, whilst considering safety and improving dosing …
Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field
A Hammond, P Pollegioni, T Persampieri… - Nature …, 2021 - nature.com
CRISPR-based gene-drives targeting the gene doublesex in the malaria vector Anopheles
gambiae effectively suppressed the reproductive capability of mosquito populations reared …
gambiae effectively suppressed the reproductive capability of mosquito populations reared …
Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae
A Cas9/guide RNA-based gene drive strain, AgNosCd-1, was developed to deliver
antiparasite effector molecules to the malaria vector mosquito, Anopheles gambiae. The …
antiparasite effector molecules to the malaria vector mosquito, Anopheles gambiae. The …
Core commitments for field trials of gene drive organisms
Gene drive organisms (GDOs), whose genomes have been genetically engineered to
spread a desired allele through a population, have the potential to transform the way …
spread a desired allele through a population, have the potential to transform the way …
Closing the gap to effective gene drive in Aedes aegypti by exploiting germline regulatory elements
MAE Anderson, E Gonzalez, JXD Ang… - Nature …, 2023 - nature.com
CRISPR/Cas9-based homing gene drives have emerged as a potential new approach to
mosquito control. While attempts have been made to develop such systems in Aedes …
mosquito control. While attempts have been made to develop such systems in Aedes …
Symbionts and gene drive: two strategies to combat vector-borne disease
Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …
Inherently confinable split-drive systems in Drosophila
CRISPR-based gene-drive systems, which copy themselves via gene conversion mediated
by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector …
by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector …
Gene drive and symbiont technologies for control of mosquito-borne diseases
Mosquito-borne diseases, such as dengue and malaria, pose a significant burden to global
health. Current control strategies with insecticides are only moderately effective. Scalable …
health. Current control strategies with insecticides are only moderately effective. Scalable …