N-heterocyclic inhibitors of TNF-alpha expression

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Heteroaryl amines as glycogen synthase kinase 3β inhibitors (GSK3 inhibitors)

EJE Freyne, PJJA Buijnsters, M Willems… - US Patent …, 2009 - Google Patents
(I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a
stereochemically isomeric form thereof, wherein ring A is a 6-membered heterocycle; R is …
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Pyrazole compounds useful as protein kinase inhibitors

D Bebbington, JD Charrier, J Golec, A Miller… - US Patent …, 2003 - Google Patents
2003-07-18 Assigned to VERTEX PHARMACEUTICALS, INCORPORATED reassignment
VERTEX PHARMACEUTICALS, INCORPORATED ASSIGNMENT OF ASSIGNORS …
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Pyrazole compounds useful as protein kinase inhibitors

R Davies, D Bebbington, R Knegtel… - US Patent …, 2008 - Google Patents
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Pyrazole compounds useful as protein kinase inhibitors

D Bebbington, JD Charrier, J Golec, A Miller… - US Patent …, 2009 - Google Patents
2016-10-14 Assigned to VERTEX PHARMACEUTICALS INCORPORATED, VERTEX
PHARMACEUTICALS (SAN DIEGO) LLC reassignment VERTEX PHARMACEUTICALS …
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Pyrazole compounds useful as protein kinase inhibitors

D Bebbington, JD Charrier, J Golec, J Green… - US Patent …, 2003 - Google Patents
2003-07-18 Assigned to VERTEX PHARMACEUTICALS, INCORPORATED reassignment
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Pyrazole compounds useful as protein kinase inhibitors

D Bebbington, JD Charrier, J Golec… - US Patent 6,727,251, 2004 - Google Patents
The present invention is in the field of medicinal chem istry and relates to compounds that
are protein kinase inhibitors, compositions containing Such compounds and methods of use …
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Optimized rollback of copy-on-write snapshot volumes

S Sangapu, JG Moore, WA Hetrick - US Patent 7,757,057, 2010 - Google Patents
The present invention is an optimized method for the rollback of copy-on-write snapshot
volumes. A method in accordance with the present invention may comprise the following …
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Pyrazole compounds useful as protein kinase inhibitors

D Bebbington, JD Charrier, J Golec, A Miller… - US Patent …, 2009 - Google Patents
2003-07-02 Assigned to VERTEX PHARMACEUTICALS, INCORPORATED reassignment
VERTEX PHARMACEUTICALS, INCORPORATED ASSIGNMENT OF ASSIGNORS …
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Monocyclic heterocycles as kinase inhibitors

RM Borzilleri, LAM Cornelius, RJ Schmidt… - US Patent …, 2008 - Google Patents
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Triazole compounds useful as protein kinase inhibitors

D Bebbington, R Knegtel, H Binch, JMC Golec… - US Patent …, 2011 - Google Patents
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