Hepatitis C virus entry

MB Zeisel, DJ Felmlee, TF Baumert - … C virus: from molecular virology to …, 2013 - Springer
Hepatitis C virus (HCV) is a hepatotropic virus and a major cause of chronic hepatitis and
liver disease worldwide. Initial interactions between HCV virions and hepatocytes are …

[HTML][HTML] Progress in the development of preventive and therapeutic vaccines for hepatitis C virus

J Torresi, D Johnson, H Wedemeyer - Journal of hepatology, 2011 - Elsevier
Hepatitis C virus (HCV) is a blood borne disease estimated to chronically infect 3% of the
worlds' population causing significant morbidity and mortality. Current medical therapy is …

Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C

JM Pestka, MB Zeisel, E Bläser… - Proceedings of the …, 2007 - National Acad Sciences
In contrast to a detailed understanding of antiviral cellular immune responses, the impact of
neutralizing antibodies for the resolution of acute hepatitis C is poorly defined. The analysis …

[PDF][PDF] Clearance of hepatitis C infection is associated with the early appearance of broad neutralizing antibody responses

WO Osburn, AE Snider, BL Wells, R Latanich… - …, 2014 - Wiley Online Library
The contribution of humoral immune responses to spontaneous control of hepatitis C virus
(HCV) infection remains unclear. We assessed neutralizing antibody (nAb) responses …

Monoclonal antibody AP33 defines a broadly neutralizing epitope on the hepatitis C virus E2 envelope glycoprotein

A Owsianka, AW Tarr, VS Juttla, D Lavillette… - Journal of …, 2005 - Am Soc Microbiol
Hepatitis C virus (HCV) remains a significant threat to the general health of the world's
population, and there is a pressing need for the development of new treatments and …

Viral and cellular determinants of the hepatitis C virus envelope-heparan sulfateInteraction

H Barth, EK Schnober, F Zhang, RJ Linhardt… - Journal of …, 2006 - Am Soc Microbiol
Cellular binding and entry of hepatitis C virus (HCV) are the first steps of viral infection and
represent a major target for antiviral antibodies and novel therapeutic strategies. We have …

[HTML][HTML] Cell entry of hepatitis C virus

B Bartosch, FL Cosset - Virology, 2006 - Elsevier
Hepatitis C virus (HCV), an important human pathogen, is an enveloped, positive-stranded
RNA virus classified in the hepacivirus genus of the Flaviviridae family. Cell attachment of …

[PDF][PDF] Hepatitis C virus entry: molecular biology and clinical implications

H Barth, TJ Liang, TF Baumert - Hepatology, 2006 - Wiley Online Library
With an estimated 170 million infected individuals, hepatitis C virus (HCV) has a major
impact on public health. A vaccine protecting against HCV infection is not available, and …

The humoral immune response to HCV: understanding is key to vaccine development

SB Cashman, BD Marsden, LB Dustin - Frontiers in immunology, 2014 - frontiersin.org
Hepatitis C virus (HCV) remains a global problem, despite advances in treatment. The low
cost and high benefit of vaccines have made them the backbone of modern public health …

Pre-clinical evaluation of a quadrivalent HCV VLP vaccine in pigs following microneedle delivery

D Christiansen, L Earnest-Silveira, B Grubor-Bauk… - Scientific reports, 2019 - nature.com
The introduction of directly acting antiviral agents (DAAs) has produced significant
improvements in the ability to cure chronic hepatitis C infection. However, with over 2% of …