Cisplatin is one of the most widely-used drugs to treat cancers. However, its nephrotoxic and
ototoxic side-effects remain major clinical limitations. Recent studies have improved our …

Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in
cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the …

In the course of examining the effect of electric fields on the growth of Escherichia coli cells,
a biological activity of platinum compounds was uncovered that led to the development of …

The chemotherapeutic use of cisplatin is limited by its severe side effects. In this study, by
conducting different omics data analyses, we demonstrated that cisplatin induces cell death …

Since the serendipitous discovery of the biological activity of cisplatin, 1 the drug has been
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …

Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid
tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging …

The many activities of metal ions in biology have stimulated the development of metal-based
therapeutics. Cisplatin, as one of the leading metal-based drugs, is widely used in treatment …

The use of cisplatin in cancer chemotherapy is limited by acquired or intrinsic resistance of
cells to the drug. Cisplatin enters the cells and its chloride ligands are replaced by water …

The platinum drugs represent a unique and important class of antitumor agents. The clinical
development of the neutral, square planar, coordination complex cis …

The application of inorganic chemistry to medicine is a rapidly develo** field, and novel
therapeutic and diagnostic metal complexes are now having an impact on medical practice …