Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant
clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment …

Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Reactive oxygen species (ROS) are essential for cellular signaling and response to stress.
The level of ROS and the type of ROS determine the ability of cells to undergo cell death …

Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules
frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns …

Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Cell death is the irreversible stop of life. It is also the basic physiological process of all
organisms which involved in the embryonic development, organ maintenance and …