Gap junctions form the cell-to-cell pathways for propagation of the precisely orchestrated
patterns of current flow that govern the regular rhythm of the healthy heart. As in most tissues …

Connexins, the protein molecules forming gap junction channels, are reduced in number or
redistributed from intercalated disks to lateral cell borders in a variety of cardiac diseases …

Objective: We tested the hypothesis that structural remodeling of cellular connections,
alterations in the expression of connexins (Cx), and an increase in fibrosis represent …

The posttranscriptional regulator, microRNA-21 (miR-21), is up-regulated in many forms of
cancer, as well as during cardiac hypertrophic growth. To understand its role, we …

Congestive heart failure is associated with a high risk of life-threatening ventricular re-
entrant arrhythmias. Down-regulation of the principal gap-junctional protein of the ventricular …

Gap junctions (GJs) channels provide the basis for intercellular communication in the
cardiovascular system for maintenance of the normal cardiac rhythm, regulation of vascular …

Gap junctions, assembled from connexins, form the cell-to-cell pathways for propagation of
the precisely orchestrated patterns of current flow that govern the regular rhythm of the …

Background Malignant ventricular arrhythmia (VA) is a major contributor to sudden cardiac
death (SCD) in patients with pulmonary arterial hypertension (PAH)-induced right heart …

Gap junctions (GJ) are important determinants of cardiac conduction and the evidence has
recently emerged that altered distribution of these junctions and changes in the expression …

The major gap junction protein expressed in the heart, connexin43 (Cx43), is highly
remodeled in the diseased heart. Usually, Cx43 is down-regulated and heterogeneously …