Modified Baihu decoction therapeutically remodels gut microbiota to inhibit acute gouty arthritis

X Wang, H Long, M Chen, Z Zhou, Q Wu, S Xu… - Frontiers in …, 2022 - frontiersin.org
Background: Acute gouty arthritis (AGA) is the most common first symptom of gout, and the
development of gout as a metabolic and immune inflammatory disease is also correlated …

The anti-inflammatory and uric acid lowering effects of Si-Miao-San on gout

L Cao, T Zhao, Y Xue, L Xue, Y Chen, F Quan… - Frontiers in …, 2022 - frontiersin.org
Background Si-Miao-San (SMS) is a well-known traditional Chinese medicine. This study
aims to evaluate the anti-inflammatory effects of SMS on gouty arthritis and its potential …

Advancements in the study of IL-6 and its receptors in the pathogenesis of gout

Z Zhang, P Wang, Q **ong, S Xu, D Kang, Z He, C Yao… - Cytokine, 2024 - Elsevier
Gout is an autoinflammatory disease characterized by the deposition of monosodium urate
crystals in or around the joints, primarily manifesting as inflammatory arthritis that recurs and …

Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway

D Qin, W Liang, Y Yu, EC Whelan, X Yuan… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Modified Simiaowan (MSM) is a six-herb formula
that has been shown to be effective in gouty arthritis (GA) has been proven, but its regulatory …

[HTML][HTML] Signaling pathways in uric acid homeostasis and gout: From pathogenesis to therapeutic interventions

S Yang, H Liu, XM Fang, F Yan, Y Zhang - International …, 2024 - Elsevier
Uric acid is a product of purine degradation, and uric acid may have multiple physiologic
roles, including the beneficial effects as an antioxidant and neuroprotector, maintenance of …

Influence of pinealectomy and long-term melatonin administration on inflammation and oxidative stress in experimental gouty arthritis

AFH Ballur, E Altinoz, G Yigitturk, MO Onal, H Elbe… - Inflammation, 2022 - Springer
Gout is an inflammatory arthritis characterized by the deposition of monosodium urate (MSU)
crystals in the joints or soft tissue. MSU crystals are potent inflammation inducers. Melatonin …

[HTML][HTML] Traditional Herbal Medicine: Therapeutic Potential in Acute Gouty Arthritis

S Wang, W Liu, B Wei, A Wang, Y Wang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Acute Gouty Arthritis (AGA) is characterized by a
rapid inflammatory reaction caused by the build-up of monosodium urate (MSU) crystals in …

Integrated Network Pharmacology and In-silico Approaches to Decipher the Pharmacological Mechanism of Dioscorea septemloba Thunb in Treating Gout and Its …

WB Liu, J Dai, X Chen, N Du, J Hu - Combinatorial Chemistry & …, 2025 - benthamdirect.com
Background Dioscorea septemloba Thunb.(DST) has demonstrated therapeutic potential in
the treatment of gout and its associated complications. However, the underlying …

The role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout

Z Zhang, P Wang, T Lei, J Guo, Y Jiang, Y Li, J Zheng… - 2024 - researchsquare.com
Background Interleukin− 6 (IL− 6) is a pleiotropic cytokine, the specific effects of which
depend on the immune microenvironment. Extensive research has confirmed the …