Molecular imaging with positron emission tomography (PET) and single photon emission
computed tomography (SPECT) is a well-established and important in vivo technique to …

N-methyl-d-aspartate receptors (NMDARs) are the main class of ionotropic receptors for the
excitatory neurotransmitter glutamate. They play a crucial role in the permeability of Ca2+ …

Background Fluoroethylnormemantine (FENM), a new Memantine (MEM) derivative,
prevented amyloid-β [25–35] peptide (Aβ25–35)-induced neurotoxicity in mice, a …

Understanding human disease on a molecular level, and translating this understanding into
targeted diagnostics and therapies are central tenets of molecular medicine. Realizing this …

Neurodegenerative disorders (NDs) include a range of chronic conditions characterized by
progressive neuronal loss, leading to cognitive, motor, and behavioral impairments …

Background Major depressive disorder is a common, recurrent illness. Recent studies have
implicated the NMDA receptor in the pathophysiology of major depressive disorder.(R, S) …

Fluoroethylnormemantine (FENM, RST-01) shows different pharmacological properties from
Memantine. The drug is neuroprotective in pharmacological and transgenic mouse models …

Fluoroethylnormemantine (FENM) is a Memantine derivative with anti-amnesic and
neuroprotective activities showed in the Aβ 25-35 pharmacological mouse model of …

Over the past few decades, several radiotracers have been developed for neuroimaging
applications, especially in PET. Because of their low steric hindrance, PET radionuclides …

Abstract Background Current therapies in Alzheimer's disease (AD), including Memantine,
have proven to be only symptomatic but not curative or disease modifying …