The “second messenger” archetype cAMP is one of the most important cellular signalling
molecules with central functions including the regulation of insulin and glucagon secretion …

Stimulation of insulin secretion by glucagon-like peptide-1 (GLP-1) and other gut-derived
peptides is central to the incretin response to ingesting nutriments. Analogues of GLP-1, and …

In diabetes, macrophages and inflammation are increased in the islets, along with β-cell
dysfunction. Here, we demonstrate that galectin-3 (Gal3), mainly produced and secreted by …

Acute hormone secretion triggered by G protein-coupled receptor (GPCR) activation
underlies many fundamental physiological processes. GPCR signalling is negatively …

Long-chain fatty acids (LCFAs) are not only energy sources but also serve as signaling
molecules. GPR120, an LCFA receptor, plays key roles in maintaining metabolic …

Objective Glucagon-like peptide 1 (GLP-1) enhances insulin secretion and protects β-cell
mass. Diabetes therapies targeting the GLP-1 receptor (GLP-1R), expressed in numerous …

Glucose metabolism is the initiator of a large number of molecular secretory processes in β
cells. Cyclic nucleotides as a second messenger are the main physiological regulators of …

Signaling networks are spatiotemporally organized in order to sense diverse inputs, process
information, and carry out specific cellular tasks. In pancreatic β cells, Ca 2+, cyclic …

Beta cells couple stimulation by glucose with insulin secretion and impairments in this
coupling play a central role in diabetes mellitus. Cyclic adenosine monophosphate (cAMP) …

Conspectus All biological processes arise through the coordinated actions of biochemical
pathways. How such functional diversity is achieved by a finite cast of molecular players …