Control of protein levels by nucleic-acid-based technologies has proven to be a useful
research tool but lacks the advantages of small molecules with respect to cell permeability …

Alzheimer's disease, the most prevalent form of dementia in the elderly, is characterized by
progressive memory loss and cognitive dysfunction. It has become increasingly clear that …

Osteoarthritis (OA) is a degenerative joint disease that involves the destruction of articular
cartilage and eventually leads to disability. Molecules that promote the selective …

While adult-born neurons in the olfactory bulb (OB) and the dentate gyrus (DG) subregion of
the hippocampus have fundamentally different properties, they may have more in common …

Biological systems involving short-range activators and long-range inhibitors can generate
complex patterns. Reaction-diffusion models postulate that differences in signaling range …

Through the natural selection process, natural products possess a unique and vast chemical
diversity and have been evolved for optimal interactions with biological macromolecules …

Mortality due to opioid use has grown to the point where, for the first time in history, opioid-
related deaths exceed those caused by car accidents in many states in the United States …

Here we report the development of a baculovirus-based delivery system that enables the
efficient incorporation of unnatural amino acids into proteins in mammalian cells. We have …

The selective degradation of target proteins with small molecules is a novel approach to the
treatment of various diseases, including cancer. We have developed a protein knockdown …

The recent renewed interest in phenotypic drug discovery has concomitantly put a focus on
target deconvolution in order to achieve drug-target identification. Even though there are …