Superenhancers as master gene regulators and novel therapeutic targets in brain tumors
HH Zhuang, Q Qu, XQ Teng, YH Dai, J Qu - Experimental & Molecular …, 2023 - nature.com
Transcriptional deregulation, a cancer cell hallmark, is driven by epigenetic abnormalities in
the majority of brain tumors, including adult glioblastoma and pediatric brain tumors …
the majority of brain tumors, including adult glioblastoma and pediatric brain tumors …
The role of thymine DNA glycosylase in transcription, active DNA demethylation, and cancer
Simple Summary Thymine DNA Glycosylase (TDG) is a DNA repair protein that plays an
important role in gene regulation. Recent studies have shown that TDG interacts with …
important role in gene regulation. Recent studies have shown that TDG interacts with …
Highly sensitive and specific fluorescence biosensor for global 5–hydroxymethylcytosine detection based on M. HhaI methyltransferase catalysis and the improved …
Y An, Y Li, X Chen, L Han, X **n, H Nie… - Sensors and Actuators B …, 2023 - Elsevier
Hydroxymethylcytosine (5hmC) is closely correlated with cancer occurrence and
development. Monitoring 5hmC level is of great significance for understanding the …
development. Monitoring 5hmC level is of great significance for understanding the …
Associations in cell type-specific hydroxymethylation and transcriptional alterations of pediatric central nervous system tumors
Although intratumoral heterogeneity has been established in pediatric central nervous
system tumors, epigenomic alterations at the cell type level have largely remained …
system tumors, epigenomic alterations at the cell type level have largely remained …
DNA strand asymmetry generated by CpG hemimethylation has opposing effects on CTCF binding
SL Thomas, TH Xu, BL Carpenter… - Nucleic Acids …, 2023 - academic.oup.com
CpG methylation generally occurs on both DNA strands and is essential for mammalian
development and differentiation. Until recently, hemimethylation, in which only one strand is …
development and differentiation. Until recently, hemimethylation, in which only one strand is …
Region‐specific DNA hydroxymethylation along the malignant progression of IDH‐mutant gliomas
T Hana, A Mukasa, M Nomura, G Nagae… - Cancer …, 2024 - Wiley Online Library
The majority of low‐grade isocitrate dehydrogenase‐mutant (IDHmt) gliomas undergo
malignant progression (MP), but their underlying mechanism remains unclear. IDHmt …
malignant progression (MP), but their underlying mechanism remains unclear. IDHmt …
[HTML][HTML] Cell-Free DNA Hydroxymethylation in Cancer: Current and Emerging Detection Methods and Clinical Applications
In the era of precision oncology, identifying abnormal genetic and epigenetic alterations has
transformed the way cancer is diagnosed, managed, and treated. 5-hydroxymethylcytosine …
transformed the way cancer is diagnosed, managed, and treated. 5-hydroxymethylcytosine …
Unidirectional alteration of methylation and hydroxymethylation at the promoters and differential gene expression in oral squamous cell carcinoma
W Zhao, L Zhu, Q Gong, S Ma, H **ong, T Su… - Frontiers in …, 2023 - frontiersin.org
Background: Oral squamous cell carcinoma (OSCC) is one of the most common types of
cancer worldwide. Although overall losses of 5-methylcytosine (5mC) and 5 …
cancer worldwide. Although overall losses of 5-methylcytosine (5mC) and 5 …
Decoding the Epigenetic Landscape: Insights into 5mC and 5hmC Patterns in Mouse Cortical Cell Types
SUMMARY The DNA modifications, 5-methylcytosine (5mC) and 5-hydroxymethylcytosine
(5hmC), represent powerful epigenetic regulators of temporal and spatial gene expression …
(5hmC), represent powerful epigenetic regulators of temporal and spatial gene expression …
[HTML][HTML] Methods in DNA methylation array dataset analysis: A review
Understanding the intricate relationships between gene expression levels and epigenetic
modifications in a genome is crucial to comprehending the pathogenic mechanisms of many …
modifications in a genome is crucial to comprehending the pathogenic mechanisms of many …