Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration with
typical survival of only 2–5 years from diagnosis. The causes of ALS are multifactorial …

In the modern “omics” era, measurement of the human exposome is a critical missing link
between genetic drivers and disease outcomes. High-resolution mass spectrometry …

Metabolomic epidemiology is the high-throughput study of the relationship between
metabolites and health-related traits. This emerging and rapidly growing field has improved …

Since the initial development of the exposome concept, much effort has been devoted to the
characterisation of the exposome through analytical, epidemiological, and toxicological …

Background: Organophosphate esters (OPEs) are common endocrine-disrupting chemicals,
and OPE exposure may be associated with type 2 diabetes (T2D). However, greater …

The development of the exposome concept has been one of the hallmarks of environmental
and health research for the last decade. The exposome encompasses the life course …

To support the use of alternative methods in regulatory assessment of chemical risks, the
concept of adverse outcome pathway (AOP) constitutes an important toxicological tool. AOP …

The exposome depicts the total exposures in the lifetime of an organism. Human exposome
comprises exposures from environmental and humanistic sources. Biological, chemical, and …

Background: Environmental contaminants (ECs) are increasingly recognized as crucial
drivers of dyslipidemia and cardiovascular disease (CVD), but the comprehensive impact …

Adverse effects associated with chemical exposures during pregnancy include several
developmental and reproductive disorders. However, considering the tens of thousands of …