Large-vessel vasculitis (LVV) manifests as inflammation of the aorta and its major branches
and is the most common primary vasculitis in adults. LVV comprises two distinct conditions …

Giant cell arteritis (GCA), the most common primary vasculitis in adults, is a granulomatous
systemic vasculitis usually affecting the aorta and its major branches, particularly the carotid …

Background/purpose Preclinical vascular inflammation models have demonstrated effective
suppression of arterial wall lesional T cells through inhibition of Janus kinase 3 and JAK1 …

Background Even after the approval of tocilizumab, substantial glucocorticoid exposure
(usually≥ 6 months) and toxicity continue to be important problems for patients with giant …

Graves' orbitopathy (GO) is the most common extrathyroidal manifestation of Graves'
disease (GD). Our aim was to assess the efficacy and safety of Tocilizumab (TCZ) in GO …

Objective To evaluate the safety and efficacy of tocilizumab (TCZ) in giant cell arteritis (GCA)
in a large North American cohort. Methods Patients with GCA treated with TCZ between …

Research into giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) has become
more important in the last few decades. Physicians are facing several challenges in …

Background Placebo-controlled clinical trials have demonstrated the efficacy of tocilizumab
(TCZ) for remission maintenance and glucocorticoid sparing in patients with giant cell …

Giant cell arteritis (GCA) is the most common vasculitis among elderly people. The clinical
spectrum of the disease is heterogeneous, with a classic/cranial phenotype, and another …

A small percentage of patients suffer from a secondary headache syndrome. It is imperative
that clinicians are able to differentiate primary headache syndromes from secondary …