Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

Chargé, Sophie BP, and Michael A. Rudnicki. Cellular and Molecular Regulation of Muscle
Regeneration. Physiol Rev 84: 209–238, 2004; 10.1152/physrev. 00019.2003.—Under …

Duchenne muscular dystrophy (DMD) is a severe, progressive, and ultimately fatal disease
of skeletal muscle wasting, respiratory insufficiency, and cardiomyopathy. The identification …

Background Major efforts have been made in the last decade to develop and improve
therapies for proximal spinal muscular atrophy (SMA). The introduction of …

▪ Abstract Myostatin is a secreted protein that acts as a negative regulator of skeletal muscle
mass. During embryogenesis, myostatin is expressed by cells in the myotome and in …

Satellite cells are quiescent muscle stem cells that promote postnatal muscle growth and
repair. Here we show that myostatin, a TGF-β member, signals satellite cell quiescence and …

Mice, and cattle with mutations in the myostatin (GDF8) gene show a marked increase in
body weight and muscle mass, indicating that this new member of the TGF-β superfamily is a …

A human therapeutic that specifically modulates skeletal muscle growth would potentially
provide a benefit for a variety of conditions including sarcopenia, cachexia, and muscular …

The widespread increase in life expectancy is accompanied by an increased prevalence of
features of physical frailty. Signs and symptoms may include sarcopenia and osteopenia …

The lack of myostatin promotes growth of skeletal muscle, and blockade of its activity has
been proposed as a treatment for various muscle-wasting disorders. Here, we have …