Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

XL Fan, Y Zhang, X Li, QL Fu - Cellular and molecular life sciences, 2020 - Springer
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …

Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

Y Shi, Y Wang, Q Li, K Liu, J Hou, C Shao… - Nature Reviews …, 2018 - nature.com
Mesenchymal stem cells (MSCs; also referred to as mesenchymal stromal cells) have
attracted much attention for their ability to regulate inflammatory processes. Their therapeutic …

Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration

MÁ Brennan, P Layrolle… - Advanced functional …, 2020 - Wiley Online Library
The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation are attributed to
their secreted factors, including extracellular vesicles (EVs) and soluble factors. The …

Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine

FJ Vizoso, N Eiro, S Cid, J Schneider… - International journal of …, 2017 - mdpi.com
Earlier research primarily attributed the effects of mesenchymal stem cell (MSC) therapies to
their capacity for local engrafting and differentiating into multiple tissue types. However …

Immunomodulatory and regenerative effects of mesenchymal stem cells and extracellular vesicles: therapeutic outlook for inflammatory and degenerative diseases

S Dabrowska, A Andrzejewska, M Janowski… - Frontiers in …, 2021 - frontiersin.org
Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent stem cells derived from
mesoderm, which can be easily isolated from many sources such as bone marrow, umbilical …

The therapeutic potential of mesenchymal stromal cells for regenerative medicine: current knowledge and future understandings

M Merimi, R El-Majzoub, L Lagneaux… - Frontiers in Cell and …, 2021 - frontiersin.org
In recent decades, research on the therapeutic potential of progenitor cells has advanced
considerably. Among progenitor cells, mesenchymal stromal cells (MSCs) have attracted …

Apoptotic vesicles activate autophagy in recipient cells to induce angiogenesis and dental pulp regeneration

Z Li, M Wu, S Liu, X Liu, Y Huan, Q Ye, X Yang, H Guo… - Molecular Therapy, 2022 - cell.com
Extracellular vesicles (EVs) derived from living cells play important roles in donor cell-
induced recipient tissue regeneration. Although numerous studies have found that cells …

Neuroinflammation as a target for treatment of stroke using mesenchymal stem cells and extracellular vesicles

S Dabrowska, A Andrzejewska, B Lukomska… - Journal of …, 2019 - Springer
Ischemic stroke is the third cause of death in the developed countries and the main reason
of severe disability. Brain ischemia leads to the production of damage-associated molecular …

Fisetin Attenuates Doxorubicin-Induced Cardiomyopathy In Vivo and In Vitro by Inhibiting Ferroptosis Through SIRT1/Nrf2 Signaling Pathway Activation

D Li, X Liu, W Pi, Y Zhang, L Yu, C Xu, Z Sun… - Frontiers in …, 2022 - frontiersin.org
Doxorubicin (DOX) is an anthracycline antibiotic that is used extensively for the
management of carcinoma; however, its clinical application is limited due to its serious …

Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages

G Turturici, R Tinnirello, G Sconzo… - American Journal of …, 2014 - journals.physiology.org
Microvesicles represent a newly identified mechanism of intercellular communication. Two
different types of microvesicles have been identified: membrane-derived vesicles (EVs) and …