Synaptopathology involved in autism spectrum disorder
Autism spectrum disorder (ASD) encompasses a group of multifactorial neurodevelopmental
disorders characterized by impaired social communication, social interaction and repetitive …
disorders characterized by impaired social communication, social interaction and repetitive …
Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …
The role of MeCP2 in the brain
J Guy, H Cheval, J Selfridge… - Annual review of cell and …, 2011 - annualreviews.org
Methyl-CpG binding protein 2 (MeCP2) was first identified in 1992 as a protein that binds
specifically to methylated DNA. Mutations in the MECP2 gene were later found to be the …
specifically to methylated DNA. Mutations in the MECP2 gene were later found to be the …
Clinical and biological progress over 50 years in Rett syndrome
In the 50 years since Andreas Rett first described the syndrome that came to bear his name,
and is now known to be caused by a mutation in the methyl-CpG-binding protein 2 (MECP2) …
and is now known to be caused by a mutation in the methyl-CpG-binding protein 2 (MECP2) …
Long-term potentiation at CA3–CA1 hippocampal synapses with special emphasis on aging, disease, and stress
A Kumar - Frontiers in aging neuroscience, 2011 - frontiersin.org
Synaptic plasticity in the mammalian central nervous system has been the subject of intense
investigation for the past four decades. Long-term potentiation (LTP), a major reflection of …
investigation for the past four decades. Long-term potentiation (LTP), a major reflection of …
The impact of MeCP2 loss-or gain-of-function on synaptic plasticity
Abstract Methyl-CpG-binding protein 2 (MeCP2) is a transcriptional regulator of gene
expression that is an important epigenetic factor in the maintenance and development of the …
expression that is an important epigenetic factor in the maintenance and development of the …
Improved survival and reduced phenotypic severity following AAV9/MECP2 gene transfer to neonatal and juvenile male Mecp2 knockout mice
Typical Rett syndrome (RTT) is a pediatric disorder caused by loss-of-function mutations in
the methyl-CpG binding protein 2 (MECP2) gene. The demonstrated reversibility of RTT-like …
the methyl-CpG binding protein 2 (MECP2) gene. The demonstrated reversibility of RTT-like …
Morphological and functional reversal of phenotypes in a mouse model of Rett syndrome
L Robinson, J Guy, L McKay, E Brockett, RC Spike… - Brain, 2012 - academic.oup.com
Rett syndrome is a neurological disorder caused by mutation of the X-linked MECP2 gene.
Mice lacking functional Mecp2 display a spectrum of Rett syndrome-like signs, including …
Mice lacking functional Mecp2 display a spectrum of Rett syndrome-like signs, including …
Breathing challenges in Rett syndrome: lessons learned from humans and animal models
Breathing disturbances are a major challenge in Rett Syndrome (RTT). These disturbances
are more pronounced during wakefulness; but irregular breathing occurs also during sleep …
are more pronounced during wakefulness; but irregular breathing occurs also during sleep …
A mouse model for MeCP2 duplication syndrome: MeCP2 overexpression impairs learning and memory and synaptic transmission
Rett syndrome and MECP2 duplication syndrome are neurodevelopmental disorders that
arise from loss-of-function and gain-of-function alterations in methyl-CpG binding protein 2 …
arise from loss-of-function and gain-of-function alterations in methyl-CpG binding protein 2 …