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[HTML][HTML] Cancer-associated fibroblasts: tumorigenicity and targeting for cancer therapy
Simple Summary Cancer-associated fibroblasts (CAFs) are found in the tumor
microenvironment and exhibit several protumorigenic functions. Preclinical studies suggest …
microenvironment and exhibit several protumorigenic functions. Preclinical studies suggest …
Targeting the tumour stroma to improve cancer therapy
Cancers are not composed merely of cancer cells alone; instead, they are complex
'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma …
'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma …
Development of quinoline-based theranostic ligands for the targeting of fibroblast activation protein
Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts and is
involved in a variety of tumor-promoting activities such as matrix remodeling, angiogenesis …
involved in a variety of tumor-promoting activities such as matrix remodeling, angiogenesis …
Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy
Melittin (MEL), a major peptide component of bee venom, is an attractive candidate for
cancer therapy. This agent has shown a variety of anti-cancer effects in preclinical cell …
cancer therapy. This agent has shown a variety of anti-cancer effects in preclinical cell …
Fibroblast heterogeneity in the cancer wound
Fibroblasts regulate the structure and function of healthy tissues, participate transiently in
tissue repair after acute inflammation, and assume an aberrant stimulatory role during …
tissue repair after acute inflammation, and assume an aberrant stimulatory role during …
Cancer associated fibroblasts: An essential role in the tumor microenvironment
Fibroblasts in the tumor stroma are well recognized as having an indispensable role in
carcinogenesis, including in the initiation of epithelial tumor formation. The association …
carcinogenesis, including in the initiation of epithelial tumor formation. The association …
TGF-β: duality of function between tumor prevention and carcinogenesis
Several mechanisms underlying tumor progression have remained elusive, particularly in
relation to transforming growth factor beta (TGF-β). Although TGF-β initially inhibits epithelial …
relation to transforming growth factor beta (TGF-β). Although TGF-β initially inhibits epithelial …
The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities
Background Breast cancer (BC), the second most common cause of cancer-related deaths,
remains a significant threat to the health and wellness of women worldwide. The tumor …
remains a significant threat to the health and wellness of women worldwide. The tumor …
Targeting of activated fibroblasts for imaging and therapy
Tumors form a complex environment consisting of a variety of non-malignant cells.
Especially cancer-associated fibroblasts have been shown to have an important role for …
Especially cancer-associated fibroblasts have been shown to have an important role for …
Understanding fibroblast activation protein (FAP): substrates, activities, expression and targeting for cancer therapy
Fibroblast activation protein (FAP) is best known for its heightened expression in tumour
stroma. This atypical serine protease has both dipeptidyl peptidase and endopeptidase …
stroma. This atypical serine protease has both dipeptidyl peptidase and endopeptidase …