The functional diversity of Aurora kinases: a comprehensive review
E Willems, M Dedobbeleer, M Digregorio, A Lombard… - Cell division, 2018 - Springer
Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …
Overview and recent advances in the treatment of neuroblastoma
SB Whittle, V Smith, E Doherty, S Zhao… - Expert review of …, 2017 - Taylor & Francis
Introduction: Children with neuroblastoma have widely divergent outcomes, ranging from
cure in> 90% of patients with low risk disease to< 50% for those with high risk disease …
cure in> 90% of patients with low risk disease to< 50% for those with high risk disease …
MYC deregulation in primary human cancers
MYC regulates a complex biological program by transcriptionally activating and repressing
its numerous target genes. As such, MYC is a master regulator of many processes, including …
its numerous target genes. As such, MYC is a master regulator of many processes, including …
Anti-cancer chalcones: Structural and molecular target perspectives
Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …
Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets
Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of prostate cancer that
most commonly evolves from preexisting prostate adenocarcinoma (PCA). Using next …
most commonly evolves from preexisting prostate adenocarcinoma (PCA). Using next …
Genetic instabilities in human cancers
C Lengauer, KW Kinzler, B Vogelstein - Nature, 1998 - nature.com
Whether and how human tumours are genetically unstable has been debated for decades.
There is now evidence that most cancers may indeed be genetically unstable, but that the …
There is now evidence that most cancers may indeed be genetically unstable, but that the …
Aurora A kinase (AURKA) in normal and pathological cell division
Temporally and spatially controlled activation of the Aurora A kinase (AURKA) regulates
centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and …
centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and …
The aurora kinases in cell cycle and leukemia
B Goldenson, JD Crispino - Oncogene, 2015 - nature.com
The Aurora kinases, which include Aurora A (AURKA), Aurora B (AURKB) and Aurora C
(AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and …
(AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and …
Aurora kinase inhibitors: current status and outlook
V Bavetsias, S Linardopoulos - Frontiers in oncology, 2015 - frontiersin.org
The Aurora kinase family comprises of cell cycle-regulated serine/threonine kinases
important for mitosis. Their activity and protein expression are cell cycle regulated, peaking …
important for mitosis. Their activity and protein expression are cell cycle regulated, peaking …
Ubiquitin ligases: cell-cycle control and cancer
KI Nakayama, K Nakayama - Nature Reviews Cancer, 2006 - nature.com
A driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the
activities of which are controlled by the ubiquitin-mediated proteolysis of key regulators such …
activities of which are controlled by the ubiquitin-mediated proteolysis of key regulators such …