Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …

Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat
diseases. However, concerns over the safety and efficacy require to be further addressed in …

Ketamine, a racemic mixture of (S)-ketamine and (R)-ketamine enantiomers, has been used
as an anesthetic, analgesic and more recently, as an antidepressant. However, ketamine …

Designer receptors exclusively activated by designer drugs (DREADDs) represent a
powerful chemogenetic technology for the remote control of neuronal activity and cellular …

We use mental models of the world—cognitive maps—to guide behavior. The lateral
orbitofrontal cortex (lOFC) is typically thought to support behavior by deploying these maps …

Astrocytes comprise a heterogeneous cell population characterized by distinct
morphologies, protein expression and function. Unlike neurons, astrocytes do not generate …

Genetically-encoded dopamine (DA) sensors enable high-resolution imaging of DA release,
but their ability to detect a wide range of extracellular DA levels, especially tonic versus …

The default mode network (DMN) of the brain is functionally associated with a wide range of
behaviors. In this study, we used functional magnetic resonance imaging (fMRI), positron …

To determine how neuronal circuits encode and drive behavior, it is often necessary to
measure and manipulate different aspects of neurochemical signaling in awake animals …

Neurovascular defects are one of the most common alterations in Alzheimer's disease (AD)
pathogenesis, but whether these deficits develop before the onset of amyloid beta (Aβ) …