The treatment of coronavirus disease 2019 (COVID-19) has been a challenge. The efficacy
of several drugs has been evaluated and variability in drug response has been observed …

Abstract Background Antiepileptic drugs (AEDs) are effective medications available for
epilepsy. However, many patients do not respond to this treatment and become resistant …

Aim: Associations between the effects of SCN1A, SCN2A, ABCC2 and UGT2B7 genetic
polymorphisms and oxcarbazepine (OXC) maintenance doses in Han Chinese epileptic …

Epilepsy is one of the most prevalent neurologic conditions, affecting almost 70 million
people worldwide. In the United States, 1.3 million women with epilepsy (WWE) are in their …

Genetic polymorphisms are related to the concentration and efficacy of oxcarbazepine
(OXC). 10-Hydroxycarbazepine (MHD) is the major pharmacologically active metabolite of …

Aim: A number of studies have demonstrated that ABCB1 and BCRP (ABCG2) actively
transport Aβ. We aimed to investigate the association of genetic variants of selected …

Aim: The purpose of this study was to investigate the potential impact of SCN1A, SCN2A and
ABCC2 gene polymorphisms on the response to antiepileptic drugs in Chinese Han patients …

Several studies examined a possible link between multidrug resistance-associated protein 2
(ABCC2) gene variants and the risk of resistance to antiepileptic drugs (AEDs) in epilepsy …

Purpose Increasing evidence suggests that genetic variants from ABCC 2 transporter may
be associated with an altered response to antiepileptic drugs (AED s). However, the …

While early pharmacogenomic studies have primarily been carried out in Western
populations, there has been a notable increase in the number of Asian studies over the past …