Equilibria of semi-volatile isothiazolinones between air and glass surfaces measured by gas chromatography and Raman spectroscopy

S Sohn, VT Huong, PD Nguyen, NH Ly, S Jang… - Environmental …, 2023 - Elsevier
Trace amounts of semi-volatile organic compounds (SVOCs) of the two isothiazolinones of 2-
methylisothiazol-3 (2H)-one (MIT) and 2-octyl-4-isothiazolin-3-one (OIT) were detected both …

Effects of methylisothiazolinone and octylisothiazolinone on development and thyroid endocrine system in zebrafish larvae

S Lee, JS Lee, Y Kho, K Ji - Journal of Hazardous Materials, 2022 - Elsevier
Methylisothiazolinone (MIT) and octylisothiazolinone (OIT) are used as preservatives and
biocides to prevent product decay or deterioration. In the present study, developmental …

Functional and dynamic mitochondrial damage by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) mixture in brain endothelial cell lines and rat …

D Kim, Y Shin, EH Kim, Y Lee, S Kim, HS Kim, HC Kim… - Toxicology letters, 2022 - Elsevier
Abstract The mixture of 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT,
chloromethylisothiazolinone) and 2-methyl-4-isothiazolin-3-one (MIT, methylisothiazolinone) …

Characteristics of exposure to chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) among humidifier disinfectant-associated lung injury (HDLI) …

DU Park, SK Park, J Kim, J Park, SH Ryu, JH Park… - Molecules, 2020 - mdpi.com
This study aimed to quantify both chloromethylisothiazolinone (CMIT) and
methylisothiazolinone (MIT) dissolved in different product brands and to characterize the …

[HTML][HTML] Next Generation Risk Assessment of biocides (PHMG-p and CMIT/MIT)-induced pulmonary fibrosis using adverse outcome pathway-based transcriptome …

JW Kim, HS Kim, HR Kim, KH Chung - Journal of Hazardous Materials, 2024 - Elsevier
Next-generation risk assessment (NGRA) has emerged as a promising alternative to non-
animal studies owing to the increasing demand for the risk assessment of inhaled toxicants …

Metabolite analysis of 14C-labeled chloromethylisothiazolinone/methylisothiazolinone for toxicological consideration of inhaled isothiazolinone biocides in lungs

JE Park, SH Ryu, S Ito, H Shin, YH Kim, J Jeon - Chemosphere, 2024 - Elsevier
Chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-methyl-4-isothiazolin-3-one (MIT) used
as preservatives in various products, including humidifier disinfectants, presents substantial …

Comparative study of two isothiazolinone biocides, 1, 2-benzisothiazolin-3-one (BIT) and 4, 5-dichloro-2-n-octyl-isothiazolin-3-one (DCOIT), on barrier function and …

D Kim, EH Kim, ON Bae - Journal of Toxicology and Environmental …, 2021 - Taylor & Francis
Isothiazolinone (IT) biocides are potent antibacterial substances used as preservatives and
disinfectants. These biocides exert differing biocidal effects and display environmental …

A commonly used biocide 2-N-octyl-4-isothiazolin-3-oneInduces blood–brain barrier dysfunction via cellular thiol modification and mitochondrial damage

D Kim, EH Kim, S Choi, KM Lim, L Tie, A Majid… - International Journal of …, 2021 - mdpi.com
Isothiazolinone (IT) biocides are potent antibacterial substances commonly used as
preservatives or disinfectants, and 2-n-Octyl-4-isothiazolin-3-one (OIT; octhilinone) is a …

Synergistic interaction of co-exposure to humidifier disinfectant chemicals CMIT/MIT and PHMG in lung injury

H Kang, S Lee, EK Jo, W Yang, YH Choi - Environmental Science and …, 2024 - Springer
A number of biocidal disinfectant chemicals are used as household products to prevent
spread of pathogens. People are commonly exposed to multiple chemicals through those …

Pulmonary toxicity of sodium dichloroisocyanurate after intratracheal instillation in sprague-dawley rats

J Yoo, H Kim, YM Lim, BI Yoon, P Kim… - Human & …, 2022 - journals.sagepub.com
In water, sodium dichloroisocyanurate (NaDCC), a source for chlorine gas generation,
releases free available chlorine in the form of hypochlorous acid, a strong oxidizing agent …