TNF-related ligands (with the exception of lymphotoxin-α) are synthesized as type II
transmembrane proteins, though many of them also have soluble forms. An increasing …

The tumor necrosis factor (TNF) superfamily (TNFSF) is a protein superfamily of type II
transmembrane proteins commonly containing the TNF homology domain. The superfamily …

Reverse signaling through CD137 ligand (CD137L) potently activates monocytes. However,
the underlying mechanism is not well elucidated. This study provides evidence that tumor …

Although the majority of research on CD137 has been directed to T cells, it is becoming
clear that this molecule has distinct functions in other lineages of cells, including non …

Background. Vascular calcification is widespread and clinically significant, contributing to
substantial morbidity and mortality. Calcifying vascular cells are partly derived from local …

Summary CD 137 ligand (CD 137 L), a member of the tumour necrosis factor family, is
expressed as a cell surface molecule. Engagement of CD 137 L on haematopoietic …

Anxiety manifestations and cognitive dysfunction are common sequelae in patients with
sepsis-associated encephalopathy (SAE). Microglia-mediated inflammatory signaling is …

We previously reported the emerging role of CD137–CD137L interaction in inflammation
and atherosclerosis. The mechanism of CD137–CD137L interaction may be related to a …

1BB is expressed on invariant (i) NKT cells, but its role is unclear. We showed previously
that iNKT cells are involved in control of monocyte numbers during influenza A virus (IAV) …

Ischemic stroke (IS) is one of the leading causes of death, and the genetic risk of which are
continuously calculated and detected by association study of single nucleotide …