The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …

Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …

ABSTRACT The Dutch NIPT Consortium, a multidisciplinary collaboration of stakeholders in
prenatal care initiated and launched the TRIDENT studies. The goal of the TRIDENT studies …

Preeclampsia is characterized by placental dysfunction and results in significant morbidity,
but reliable early prediction remains challenging. We investigated whether clinically …

Background Aberrant embryo implantation and suboptimal placentation can lead to (severe)
complications such as preeclampsia and fetal growth restriction later in pregnancy. Current …

Defining the number and abundance of different cell types in tissues is important for
understanding disease mechanisms as well as for diagnostic and prognostic purposes …

Purpose While cell-free DNA (cfDNA) screening has emerged as a screening modality for
common aneuploidies, further research and several publications over the past decade …

Abstract Purpose of Review This review summarizes the potential of cell-free nucleic acids
for predicting preeclampsia, contrasts them with other methods, and discusses these …

Exercising regularly promotes health, but these benefits are complicated by acute
inflammation induced by exercise. A potential source of inflammation is cell-free DNA …

Presymptomatic prediction of preeclampsia (PE) is crucial to enable early prophylactic
treatment. Current screening tools are either complex or lack predictive value. We recently …