Thermostable enzymes are enzymes that can withstand elevated temperatures as high as
50° C without altering their structure or distinctive features. The potential of thermostable …

Nowadays, pharmaceutical industry demands competitive and eco-friendly processes for
active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole …

Nucleosides are ubiquitous to life and are required for the synthesis of DNA, RNA, and other
molecules crucial for cell survival. Despite the notoriously difficult organic synthesis of …

Introduction Microorganisms colonize a wide range of natural and artificial environments.
Even though most of them are unculturable in laboratory conditions, some ecosystems are …

One of the major drawbacks of the industrial implementation of enzymatic processes is the
low operational stability of the enzymes under tough industrial conditions. In this respect, the …

Due to their similarity to natural counterparts, nucleic acid derivatives (nucleobases,
nucleosides, and nucleotides, among others) are interesting molecules for pharmaceutical …

Insight into the catalytic mechanism of Lactobacillus leichmannii nucleoside 2′-
deoxyribosyltransferase (LlNDT) has been gained by calculating a quantum mechanics …

In our search for novel biocatalysts for the synthesis of nucleic acid derivatives, we found a
good candidate in a putative dual-domain hypoxanthine-guanine phosphoribosyltransferase …

The unicellular Chroococcidiopsis is extremely resistant to desiccation, UV-irradiation, salt
toxicity and high temperature. It requires only low light intensities for growth, and is protected …

Nucleoside-2′-deoxyribosyl-transferases (NDTs) catalyze a transglycosylation reaction
consisting of the exchange of the 2′-deoxyribose moiety between a purine and/or …