HFIP in organic synthesis

HF Motiwala, AM Armaly, JG Cacioppo… - Chemical …, 2022 - ACS Publications
1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Electro-organic synthesis–a 21 st century technique

D Pollok, SR Waldvogel - Chemical science, 2020 - pubs.rsc.org
The severe limitations of fossil fuels and finite resources influence the scientific community to
reconsider chemical synthesis and establish sustainable techniques. Several promising …

Making electrochemistry easily accessible to the synthetic chemist

C Schotten, TP Nicholls, RA Bourne, N Kapur… - Green …, 2020 - pubs.rsc.org
A significantly renewed interest in synthetic electrochemistry is apparent in the increasing
number of publications over the last few years. Electrochemical synthesis offers a mild …

Counter electrode reactions—important stumbling blocks on the way to a working electro‐organic synthesis

M Klein, SR Waldvogel - Angewandte Chemie International …, 2022 - Wiley Online Library
Over the past two decades, electro‐organic synthesis has gained significant interest, both in
technical and academic research as well as in terms of applications. The omission of …

Versatile tools for understanding electrosynthetic mechanisms

ECR McKenzie, S Hosseini, AGC Petro… - Chemical …, 2021 - ACS Publications
Electrosynthesis is a popular, green alternative to traditional organic methods.
Understanding the mechanisms is not trivial yet is necessary to optimize reaction processes …

Site‐selective electrochemical Benzylic C− H amination

ZW Hou, DJ Liu, P **ong, XL Lai… - Angewandte Chemie …, 2021 - Wiley Online Library
Abstract C− H/N‐H cross‐coupling is an ideal strategy to synthesize various amines but
remains challenging owing to the requirement for sacrificial chemical oxidants and the …

Merging shuttle reactions and paired electrolysis for reversible vicinal dihalogenations

X Dong, JL Roeckl, SR Waldvogel, B Morandi - Science, 2021 - science.org
Vicinal dibromides and dichlorides are important commodity chemicals and indispensable
synthetic intermediates in modern chemistry that are traditionally synthesized using …

Electrochemical borylation of alkyl halides: fast, scalable access to alkyl boronic esters

B Wang, P Peng, W Ma, Z Liu, C Huang… - Journal of the …, 2021 - ACS Publications
Herein, a fast, scalable, and transition-metal-free borylation of alkyl halides (X= I, Br, Cl)
enabled by electroreduction is reported. This process provides an efficient and practical …

Continuous Flow Electrochemistry Enables Practical and Site‐Selective C− H Oxidation

TS Chen, H Long, Y Gao, HC Xu - … Chemie International Edition, 2023 - Wiley Online Library
The selective oxygenation of ubiquitous C (sp3)− H bonds remains a highly sought‐after
method in both academia and the chemical industry for constructing functionalized organic …

Epoxide electroreduction

C Huang, W Ma, X Zheng, M Xu, X Qi… - Journal of the American …, 2021 - ACS Publications
Selective hydrogenation of epoxides would be a direct and powerful approach for alcohol
synthesis, but it has proven to be elusive. Here, electrochemically epoxide hydrogenation …