Mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) protein are highly
prevalent in cancer. However, small-molecule concepts that address oncogenic KRAS …

Gasdermins (GSDMs) are pore-forming proteins that execute pyroptosis for immune
defense. GSDMs are two-domain proteins activated by proteolytic removal of the inhibitory …

Hormones and neurotransmitters are essential to homeostasis, and their disruptions are
connected to diseases ranging from cancer to anxiety. The differential reactivation of …

VISTA, an inhibitory myeloid-T-cell checkpoint, holds promise as a target for cancer
immunotherapy. However, its effective targeting has been impeded by issues such as rapid …

The Pauson-Khand reaction has in the past 50 years become one of the most common
cycloaddition reactions in chemistry. Coupling two unsaturated bonds with carbon …

Summary The recently emerged BA. 2.86, JN. 1, EG. 5, EG. 5.1, and HV. 1 variants have a
growth advantage. In this study, we explore the structural bases of receptor binding and …

Respiratory syncytial virus (RSV) is a common cause of acute lower respiratory tract
infection in infants, older adults and the immunocompromised. Effective directly acting …

Proteins frequently undergo covalent modification at the post-translational level, which
involves the covalent attachment of chemical groups onto amino acids. This can entail the …

XDSGUI is a lightweight graphical user interface (GUI) for the XDS, SHELX and
ARCIMBOLDO program packages that serves both novice and experienced users in …

Two years on from the initial release of AlphaFold, we have seen its widespread adoption as
a structure prediction tool. Here, we discuss some of the latest work based on AlphaFold …