Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood
system homeostasis throughout life and underlies the curative capacity of clinical HSC …

Hematopoietic stem cell (HSC) self-renewal and aging are tightly regulated by paracrine
factors from the bone marrow niche. However, whether HSC rejuvenation could be achieved …

Osteoarthritis (OA) is a degenerative multifactorial disease with concomitant structural,
inflammatory, and metabolic changes that fluctuate in a temporal and patient-specific …

In the bone marrow (BM) microenvironment, where breast cancer (BC)-disseminated tumor
cells (DTCs) can remain dormant for decades, NG2+/Nestin+ mesenchymal stem cells …

The highly heterogeneous characteristics of Wharton's jelly mesenchymal stem cells (WJ‐
MSCs) may be responsible for the poor clinical outcomes and poor reproducibility of …

Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-
autonomous process, which is the focus of another review in the same issue of …

Ex vivo retrovirally mediated gene therapy has been shown within the last 20 yr to correct
the T cell immunodeficiency caused by γc-deficiency (SCID X1) and adenosine deaminase …

The processes that govern human haematopoietic stem cell (HSC) self-renewal and
engraftment are poorly understood and challenging to recapitulate in culture to reliably …

Ex vivo-expanded mesenchymal stem cells (MSCs) have been demonstrated to be a
heterogeneous mixture of cells exhibiting varying proliferative, multipotential, and …