This review focuses on recent research related to the avian ovary and, in particular, cellular
mechanisms mediating embryonic growth of the ovary, postembryonic follicular …

Transgenesis and genome editing in birds are based on a unique germline transmission
system using primordial germ cells (PGCs), which is quite different from the mammalian …

Precise self-renewal of the germ cell lineage is fundamental to fertility and reproductive
success. The early precursors for the germ lineage, primordial germ cells (PGCs), survive …

The CRISPR/Cas9 system has been applied in a large number of animal and plant species
for genome editing. In chickens, CRISPR has been used to knockout genes in somatic …

In macrolecithal species, cryopreservation of the oocyte and zygote is not possible due to
the large size and quantity of lipid deposited within the egg. For birds, this signifies that …

Genetically modified animals continue to provide important insights into the molecular basis
of health and disease. Research has focused mostly on genetically modified mice, although …

Generating transgenic and gene edited mammals involves in vitro manipulation of oocytes
or single cell embryos. Due to the comparative inaccessibility of avian oocytes and single …

Transgenic animal platforms for the discovery of human monoclonal antibodies have been
developed in mice, rats, rabbits and cows. The immune response to human proteins is …

Biosecurity and sustainability in poultry production requires reliable germplasm
conservation. Germplasm conservation in poultry is more challenging in comparison to other …

Heavy chain-only antibodies have found many applications where conventional heavy-light
heterodimeric antibodies are not favorable. Heavy chain-only antibodies with their single …