The mixed venous-to-arterial carbon dioxide (CO 2) tension difference [P (va) CO 2] is the
difference between carbon dioxide tension (PCO 2) in mixed venous blood (sampled from a …

Fluid administration is a cornerstone of treatment of critically ill patients. The aim of this
review is to reappraise the pathophysiology of fluid therapy, considering the mechanisms …

Objectives: The American College of Critical Care Medicine provided 2002 and 2007
guidelines for hemodynamic support of newborn and pediatric septic shock. Provide the …

Background This study was design to investigate the prognostic value for death at day-28 of
lactate course and lactate clearance during the first 24 hours in Intensive Care Unit (ICU) …

Introduction Since normal or high central venous oxygen saturation (ScvO 2) values cannot
discriminate if tissue perfusion is adequate, integrating other markers of tissue hypoxia, such …

The assessment and monitoring of the tissue perfusion is extremely important in critical
conditions involving circulatory shock. There is a wide range of established methods for the …

The pathophysiology of sepsis alters drug pharmacokinetics, resulting in inadequate drug
exposure and target-site concentration. Suboptimal exposure leads to treatment failure and …

Sepsis remains a leading cause of maternal morbidity and mortality. Recognition and
treatment of maternal sepsis are often delayed due to the physiological adaptations of …

The concept of intensive care units (ICU) has existed for almost 70 years, with outstanding
development progress in the last decades. Multidisciplinary care of critically ill patients has …

Introduction The purpose of this study was to evaluate the clinical relevance of high values
of central venous-to-arterial carbon dioxide difference (PCO 2 gap) in high-risk surgical …