Neurodevelopmental impairments are the most common extracardiac morbidities among
patients with complex congenital heart disease (CHD) across the lifespan. Robust clinical …

Converging evidence from clinical and preclinical studies suggests that fetal vulnerability to
adverse prenatal exposures increases the risk for neuropsychiatric diseases such as autism …

Background Congenital heart disease (CHD) remains a significant risk factor for neurologic
injury because altered fetal hemodynamics may be unable to support typical brain …

Embryonic neurogenesis can be defined as a period of prenatal development during which
divisions of neural stem and progenitor cells give rise to neurons. In the central nervous …

Background Congenital heart disease (CHD) is common and is associated with impaired
early brain development and neurodevelopmental outcomes, yet the exact mechanisms …

Abstract Background Congenital heart defects (CHDs) affect approximately half of
individuals with Down syndrome (DS), but the molecular reasons for incomplete penetrance …

Congenital heart disease is associated with impaired early brain development and adverse
neurodevelopmental outcomes. This study investigated how individualized measures of …

Adverse intrauterine events may profoundly impact fetal risk for future adult diseases. The
mechanisms underlying this increased vulnerability are complex and remain poorly …

Antenatal assessment of congenital heart disease and associated anomalies by ultrasound
has improved perinatal care. Fetal cardiovascular MRI and fetal brain MRI are rapidly …

Purpose Human brain development during gestation is complex, as both structure and
function are rapidly forming. Structural imaging methods using MRI are well developed to …